Contemporary application of autologous muscle-derived cells for urinary sphincter regeneration

Conclusions from the pooled analyses indicate that injection of AMDC-USR across a range of dosages appears safe. Efficacy data suggest a dose response with more patients responsive to the higher doses of AMDC-USR.ConclusionApplications for utilization of autologous cellular therapies for treatment of SUI, and conceivably multiple additional indications, are approaching realization. Multiple Phase III randomized, placebo-controlled studies for AMDC-USR are concluding or ongoing to launch this regenerative option for the millions of patients who may ultimately benefit.
Source: World Journal of Urology - Category: Urology & Nephrology Source Type: research

Related Links:

We report a patient with relapsing-remitting multiple sclerosis, who developed rheumatoid arthritis after exposure to natalizumab. While some multiple sclerosis therapies are known to unmask autoimmune conditions, natalizumab is rarely implicated as a cause of alternative autoimmunity. This case illustrates an unusual clinical scenario which may support recent scientific work suggesting that when natalizumab blocks T helper 1 cells from entering the central nervous system, T helper 17 cells may continue to migrate into immune-privileged spaces and cause pathologic inflammation.Brief Background: Multiple sclerosis (MS) pati...
Source: Multiple Sclerosis and Related Disorders - Category: Neurology Source Type: research
Urinary incontinence (UI) is highly prevalent and affects the lives of many men and women. We aimed to conduct a qualitative evidence synthesis (QES) to explore the experience of living with UI and to develop ...
Source: BMC Urology - Category: Urology & Nephrology Authors: Tags: Research article Source Type: research
;rez López Sánchez There is a high prevalence of comorbidities among patients with chronic obstructive pulmonary disease (COPD). Comorbidities are likely common in patients with any COPD degree and are associated with increased mortality. The aim of this study was to determine the prevalence of thirty-one different COPD comorbidities and to evaluate the association between physical activity (PA) levels in people with COPD residing in Spain. Cross-sectional data from the Spanish National Health Survey 2017 were analysed. A total of 601 adults (52.2% females) with COPD aged 15 to 69 participated in this ...
Source: International Journal of Environmental Research and Public Health - Category: Environmental Health Authors: Tags: Article Source Type: research
Fecal incontinence frequently occurs after total mesorectal excision for rectal cancer. This prospective study analyzed predictive factors and the impact of pelvic intraoperative neuromonitoring at different f...
Source: World Journal of Surgical Oncology - Category: Cancer & Oncology Authors: Tags: Research Source Type: research
Conclusions: This meta-analysis indicated that BTX-A 200U and 300U are more effective than placebo in the treatment of NDO, with minimal, local, and manageable adverse events. Furthermore, BTX-A 300U and 200U could also improve detrusor compliance of IOAB. However, more RCTs would still be necessary to explore the effect of BTX-A on management of UI in NDO and IOAB patients.
Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research
Authors: Yan J, Ma L Abstract BACKGROUND The aim of this study was to investigate the clinical effect of tunnel-like fistulectomy plus draining seton combined with incision of internal opening of anal fistula (TFSIA) in the treatment of high transsphincteric anal fistula. MATERIAL AND METHODS There were 80 patients with high transsphincteric anal fistula randomly divided into TFSIA group and control group, 40 cases in each group. The control group was treated with cutting seton, and the seton was tightened weekly after discharge from the hospital until the seton dropped off. In the TFSIA group, the anal fistula was...
Source: Medical Science Monitor - Category: Research Tags: Med Sci Monit Source Type: research
The sacral neuromodulation market continues to see disruption as Medtronic scores a CE mark for its InterStim Micro neurostimulator and InterStim SureScan MRI leads, clearing the technologies for sale in Europe. InterStim Micro is a rechargeable device that delivers sacral neuromodulation (SNM) therapy to treat overactive bladder (OAB), fecal incontinence (FI) and non-obstructive urinary retention. It is 80% smaller than the existing recharge-free InterStim II neurostimulator and could reduce the need for battery replacement surgeries due to its life of 15 years. It also features Medtronic'sÂ&...
Source: MDDI - Category: Medical Devices Authors: Tags: Business Source Type: news
Conclusion: The Portuguese version of the ICIQ-FLUTS questionnaire showed strong correlation to ICIQ-SF questionnaire and satisfactory values to test-retest and internal consistency.
Source: International Braz J Urol - Category: Urology & Nephrology Source Type: research
This cohort study compares functional outcomes, including sexual and bowel function and urinary incontinence, associated with active surveillance, surgery, or radiation therapy 5 years after treatment.
Source: JAMA - Category: General Medicine Source Type: research
Journal of Wound Care,Volume 29, Issue 1, Page 18-26, January 2020.
Source: Journal of Wound Care - Category: Nursing Authors: Source Type: research
More News: Incontinence | Statistics | Study | Urology & Nephrology