GSE141931 Mycobacterium tuberculosis is protected from NADPH oxidase and LC3-associated phagocytosis by the LCP protein CpsA

Contributors : Stefan K öster ; Sandeep Upadhyay ; Pallavi Chandra ; Kadamba Papavinasasundaram ; Guozhe Yang ; Amir Hassan ; Steven J Grigsby ; Ekansh Mittal ; Heidi S Park ; Victoria Jones ; Fong-Fu Hsu ; Mary Jackson ; Christopher M Sassetti ; Jennifer A PhilipsSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusMycobacterium tuberculosis ’success as a pathogen comes from itsability to evade degradation by macrophages. Normally macro-phages clear microorganisms that activate pathogen-recognitionreceptors (PRRs) through a lysosomal-trafficking pathway called“LC3-associated phagocytosis”(LAP). AlthoughM.tuberculosisac-tivates num erous PRRs, for reasons that are poorly understoodLAP does not substantially contribute toM.tuberculosiscontrol.LAP depends upon reactive oxygen species (ROS) generated byNADPH oxidase, butM.tuberculosisfails to generate a robustoxidative response. Here, we show that CpsA, a LytR-CpsA-Psr(LCP) domai n-containing protein, is required forM.tuberculosisto evade killing by NADPH oxidase and LAP. Unlike phagosomescontaining wild-type bacilli, phagosomes containing theΔcpsAmutant recruited NADPH oxidase, produced ROS, associated withLC3, and matured into antibacterial lysosomes. Moreover, CpsAwas su fficient to impair NADPH oxidase recruitment to fungal par-ticles that are normally cleared by LAP. Intracellular survival of theΔcpsAmutant was largely restored in macrophages missing LAPco...
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research

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CONCLUSIONS.: There is a great variability of mutations associated with resistance to anti-tuberculosis drugs that have been reported in Peru, and they are systematized in this report. These mutations must be taken into account for the development of diagnostic devices or selection of diagnostic tests to be applied in our country. PMID: 31967255 [PubMed - in process]
Source: Revista Peruana de Medicina de Experimental y Salud Publica - Category: International Medicine & Public Health Tags: Rev Peru Med Exp Salud Publica Source Type: research
A pediatric healthcare worker in Michigan had tuberculosis and didn't know it while working in several locations over nine months, the state's health department said.ment said.
Source: - Health - Category: Consumer Health News Source Type: news
Sattamma, a daily labourer in the Rangareddy district of southern India’s Telangana state, says that even though she no longer has Hansen’s Disease, she remains discriminated against because of it. Credit: Stella Paul/IPSBy Stella PaulHYDERABAD, India , Jan 23 2020 (IPS) Fifteen years ago, Sattamma – a daily labourer in the Rangareddy district of southern India’s Telangana state – was abandoned by her husband after she was diagnosed with Hansen’s Disease. Last October, while her neighbours were celebrating Diwali, Sattamma was homeless again as her landlord threw her out of the house aft...
Source: IPS Inter Press Service - Health - Category: International Medicine & Public Health Authors: Tags: Asia-Pacific Development & Aid Editors' Choice Featured Global Headlines Health Human Rights Latin America & the Caribbean Poverty & SDGs TerraViva United Nations Brazil Hansen's disease India Indonesia leprosy Source Type: news
CONCLUSION: Although miliary sarcoidosis is rare, physicians should consider sarcoidosis in the differential diagnosis with conditions like tuberculosis, malignancy, and pneumoconiosis when patients present with miliary opacities who do not respond to the traditional treatment. PMID: 31964332 [PubMed - in process]
Source: Current Medical Imaging Reviews - Category: Radiology Tags: Curr Med Imaging Rev Source Type: research
CONCLUSION: Tuberculosis can be difficult to diagnose when it only manifests as pericardial effusion especially if the time for exposure is long before the appearance of symptoms and admission. PMID: 31964331 [PubMed - in process]
Source: Current Medical Imaging Reviews - Category: Radiology Tags: Curr Med Imaging Rev Source Type: research
[AIM] Maputo -Mozambique's Coordination Mechanism for the Global Fund to Fight AIDS, Tuberculosis and Malaria on Wednesday reached consensus on the need to create strong and resilient health systems that can respond effectively to the challenges of the Sustainable Development Goals (SDGs).
Source: AllAfrica News: Health and Medicine - Category: African Health Source Type: news
Publication date: Available online 22 January 2020Source: Journal de Mycologie MédicaleAuthor(s): Arghadip Samaddar, Anuradha Sharma, Twishi ShrimaliAbstractAcrophialophora fusispora is a soil-borne fungus rarely implicated in human infections. Here, we report a case of pulmonary infection due to A. fusispora in a 59-year-old male who presented with productive cough and gradually progressive dyspnoea for 20 days. He had a past history of pulmonary tuberculosis and was a known case of chronic obstructive pulmonary disease for past five years. He was diagnosed with mixed connective tissue disease and had been receivin...
Source: Journal of Medical Mycology - Category: Biology Source Type: research
Publication date: Available online 23 January 2020Source: Inorganica Chimica ActaAuthor(s): Samet Belveren, Samet Poyraz, Mahmut Ülger, Christopher M. Pask, H. Ali DöndaƟ, José M. SansanoAbstractThe synthesis of a mononuclear octahedral [Prolinate2-Na(MeOH)4]−H+ complex is achieved from a [3+2] cycloadduct with excess of NaOMe in methanol. The slow crystallization provides the hexacoordinated complex stabilized by four molecules of solvent. The antibacterial, antifungal and anti-tuberculosis activity of this compound is also evaluated.Graphical abstract
Source: Inorganica Chimica Acta - Category: Chemistry Source Type: research
[MSF] New York -Doctors Without Borders/M édecins Sans Frontières (MSF) protested in front of the New York Stock Exchange in New York today, demanding the pharmaceutical corporation Johnson&Johnson (J&J) make the tuberculosis (TB) drug bedaquiline available for all people with drug-resistant TB (DR-TB) for no more than a dollar a day. The price of this crucial drug must be lowered to reflect the joint contributions made to its research and development by taxpayers and the global scientific and TB co
Source: AllAfrica News: Health and Medicine - Category: African Health Source Type: news
Publication date: Available online 21 January 2020Source: Preventive Veterinary MedicineAuthor(s): Laetitia Canini, Benoit DurandAbstractFrance was recognized officially bovine tuberculosis (bTB) free by the European Union in 2001, however an increase of bTB detections has been reported since 2004. Even though the recommended method for bTB control is whole herd depopulation, test-and-cull protocols have been authorized in pilot areas since 2008 and in the rest of France since 2014. BTB impact at the state level and on trade has been thoroughly studied, however the consequences of these control measures at a farm level are...
Source: Preventive Veterinary Medicine - Category: Veterinary Research Source Type: research
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