Synchronous Metastatic Colon Cancer and the Importance of Primary Tumor Laterality – A National Cancer Database Analysis of Right- Versus Left-Sided Colon Cancer

Publication date: Available online 12 December 2019Source: The American Journal of SurgeryAuthor(s): Beiqun Zhao, Nicole E. Lopez, Samuel Eisenstein, Gabriel T. Schnickel, Jason K. Sicklick, Sonia L. Ramamoorthy, Bryan M. ClaryABSTRACTBackgroundThe role of laterality for patients with synchronous metastatic colon cancer (SMCC) is not well-defined.MethodsUsing the National Cancer Database (2010-2015), we compared patients with metastatic right- (RCC) versus left-sided colon cancer (LCC). We performed Kaplan-Meier analysis to compare overall survival (OS) for each metastatic site and utilized adjusted Cox proportional hazard analysis to identify predictors of OS.ResultsPatients with RCCs were more likely to be older, female, and have more comorbidities. LCCs were more likely to metastasize to liver and lung, whereas RCCs were more likely to metastasize to peritoneum and brain. There was equal likelihood to metastasize to bone. OS was significantly longer for LCCs for all metastatic sites. After controlling for multiple variables, RCC (HR 1.426, p
Source: The American Journal of Surgery - Category: Surgery Source Type: research

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The majority of doctors will tell you that there is nothing you can do to reverse fatty liver and that health problems such as cirrhosis and liver failure may be in your future that they will address with the awful “solution” of liver transplant. The truth is the opposite: fatty liver is easily and readily reversible in virtually everybody, provided you take action before irreversible changes take place and are given the right information and tools. In this video, I discuss the three basic phenomena that drive fat deposition, liver damage, and inflammation that lead to this condition: Carbohydrate consumption ...
Source: Wheat Belly Blog - Category: Cardiology Authors: Tags: Open bowel flora carbohydrates carbs Inflammation NAFLD nash triglycerides undoctored wheat belly Source Type: blogs
CONCLUSION: VUGX01 can effectively block proliferation and induce apoptosis of certain type of cancer cells, even it's predicted by high LASSO score, but it is not an effective RTKs inhibitor, it may inhibit cell growth through acting as a novel ligand to one or several GPCRs. PMID: 31951182 [PubMed - as supplied by publisher]
Source: Current Cancer Drug Targets - Category: Cancer & Oncology Authors: Tags: Curr Cancer Drug Targets Source Type: research
Brain, lung, and colon tissue experience deleterious immune-related adverse events when immune-oncological agents or radiation are administered. However, there is a paucity of information regarding whether the addition of radiation to immuno-oncological regimens exacerbates the tissue inflammatory response. We used a murine model to evaluate sub-acute tissue damage and the systemic immune response in C57Bl/6 mice when administered systemic anti-programmed cell death protein 1 (αPD-1) immunotherapy alone or in combination with stereotactic fractionated 10 gray/5 X-ray radiation to normal brain, lung or colon tissue. T...
Source: Frontiers in Oncology - Category: Cancer & Oncology Source Type: research
Publication date: Available online 8 January 2020Source: Pharmacological ResearchAuthor(s): Kishore Banik, Abhishek Manoj Ranaware, Harsha Choudhary, Nitesh Thakur, Sosmitha Girisa, Vishwas Deshpande, Lu Fan, Savita Pravin Nalawade, Gautam Sethi, Ajaikumar B. KunnumakkaraAbstractThe World Health Organization (WHO) has documented that cancer is the second foremost reason for death worldwide. Various factors are responsible for cancer, for instance, exposure to different physical, chemical and biological carcinogens, infections, hereditary, poor dietary habits and lifestyle etc. Cancer is a preventable disease if detected at...
Source: Pharmacological Research - Category: Drugs & Pharmacology Source Type: research
Abstract Postoperative cognitive dysfunction (POCD) is a common long-term complication of surgery, which may have serious consequences for quality of life and may even result in irreversible cognitive deficits. With the aging of society, more patients are having surgery due to cancer. However, few studies have focused on postoperative cognitive function in cancer patients. Here, MC38 colon cancer cells (2 x 105/mouse) were injected subcutaneously into 2-month-old C57BL/6J mice 3 weeks before surgery to repair tibial fractures in order to establish a model of a tumor-bearing animal undergoing surgery. Both Morris w...
Source: Brain Research - Category: Neurology Authors: Tags: Brain Res Source Type: research
Conclusion A great deal of progress is being made in the matter of treating aging: in advocacy, in funding, in the research and development. It can never be enough, and it can never be fast enough, given the enormous cost in suffering and lost lives. The longevity industry is really only just getting started in the grand scheme of things: it looks vast to those of us who followed the slow, halting progress in aging research that was the state of things a decade or two ago. But it is still tiny compared to the rest of the medical industry, and it remains the case that there is a great deal of work yet to be done at all...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
Mutational damage to nuclear DNA occurs constantly in all cells, and not all of it is successfully repaired. Setting aside recent evidence for cycles of damage and repair to cause epigenetic changes characteristic of aging, most unrepaired mutational damage has no meaningful consequence. It occurs in somatic cells that have few cell divisions left, so will not spread, and these cells will die or become senescent and be destroyed once they reach the Hayflick limit. It occurs in genes that are not active in the tissue in question, so even in long-lived somatic cells that do not replicate, such as those of the central nervous...
Source: Fight Aging! - Category: Research Authors: Tags: Medicine, Biotech, Research Source Type: blogs
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Source: Cliffside Malibu - Category: Addiction Authors: Tags: Alcohol Alcohol Rehab Information Alcoholism alcohol abuse alcohol dependence alcohol dependency alcohol detox alcohol treatment alcohol treatment center alcohol treatment facility Alcoholics Anonymous Source Type: blogs
Autophagy is considered to be another restorative focus for the treatment of brain tumors. Although several research have demonstrated that melatonin induces autophagy in colon cancer and hepatoma cells, there...
Source: BMC Neuroscience - Category: Neuroscience Authors: Tags: Research article Source Type: research
AbstractIn the present study, a meta ‐analysis was carried out to clarify the association between disinfection byproducts (DBPs) in drinking water and human cancer risk worldwide. Kidney, colorectal, esophagus, urinary bladder, brain, breast, leukemia, lung, and rectum cancers were selected to perform this analysis. According to pref erred reporting items for systematic review and meta‐analysis protocol (PRISMA) guidelines, the relevant studies were identified and selection criteria (inclusion and exclusion criteria) were applied. Next, effective subgroups in these studies (gender, type of drinking water source, and ty...
Source: Environmental Quality Management - Category: Environmental Health Authors: Tags: RESEARCH ARTICLE Source Type: research
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