No association between early maternal HbA1c and offspring birthweight among women without pre-existing diabetes in Greenland.

No association between early maternal HbA1c and offspring birthweight among women without pre-existing diabetes in Greenland. Int J Circumpolar Health. 2020 Dec;79(1):1702798 Authors: Rasmussen KV, Nielsen KK, Pedersen ML Abstract Studies of the association between maternal blood glucose measured by glycated haemoglobin (HbA1c) during pregnancy and the offspring's birthweight have been heterogeneous. The aim of this study was to examine the association between maternal HbA1c level before gestational week 20 and the offspring's birthweight among predominantly indigenous women in Greenland. A retrospective cohort study including all women (n = 503) and their offspring delivered from September 2015 to September 2016 at Queen Ingrid's Hospital in Nuuk was conducted. Data were obtained from the electronic medical record. Linear regression models were used to analyse the effect of maternal HbA1c on the offspring's birthweight with adjustment and stratification for relevant confounders and effect modifiers. Birthweight increased with 3.3 g per mmol/mol increase in HbA1c. Yet, no significant association between maternal HbA1c and the offspring's birthweight was found after adjustment for maternal age, ethnicity, residence, smoking, and parity (β = 0.058, p = 0.711). Among obese women, a borderline significant positive association (β = 0.657, p = 0.059) was found. For term newborns, this corresponded to an increase in birthweight of 31 g per mmol/mol inc...
Source: International Journal of Circumpolar Health - Category: International Medicine & Public Health Tags: Int J Circumpolar Health Source Type: research

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AbstractObjectiveTo evaluate the long-term pediatric neuropsychiatric morbidity of children born to obese patients.Study designA population-based cohort analysis was performed comparing all deliveries of obese (maternal pre-pregnancy body mass index of 30  kg/m2 or more) and non-obese patients between 1991 and 2014 at a single tertiary medical center. Hospitalizations of the offspring up to the age of 18  years involving neuropsychiatric morbidities were evaluated according to a pre-defined set of ICD-9 codes, including autistic, eating, sleeping and movement disorders, cerebral palsy, developmental disorders, an...
Source: Archives of Gynecology and Obstetrics - Category: OBGYN Source Type: research
ConclusionResults of this study support that the TyG index may be a useful indicator to detect MONW phenotype and associated cardiovascular risk factors.
Source: Journal of Endocrinological Investigation - Category: Endocrinology Source Type: research
Molina Seguí F, Montoya Cossio J, Méndez Trujeque J, Nolascozhu Morán V, Sirahuén Neri Ruz E, Peralta Sánchez AE, Santa Rita Escamilla MT, Tena Alavez G, Riobó Serván P, Laviada Molina H Abstract Non-nutritive sweeteners (NNS) are food additives that have been used as a possible tool to reduce energy and sugar intake. There is a scientific debate around the real benefits of their use. NNS are substances widely evaluated in the scientific literature. Their safety is reviewed by international regulatory health agencies. Health professionals and consumers often lack e...
Source: Nutricion Hospitalaria - Category: Nutrition Authors: Tags: Nutr Hosp Source Type: research
Indigenous populations worldwide have a high prevalence of type 2 diabetes mellitus (T2D),[1] and early age of onset.[2] The causes of increased rates of T2D are likely multiple and complex. However, social determinants of health appear to be associated with differences in prevalence across populations, including in youth.[3] The prevalence of T2D is directly related to the prevalence of obesity which is also influenced by social determinants of health. Understanding the relationship between social determinants of health and neonatal adiposity may inform early life interventions to improve metabolic health.
Source: Diabetes Research and Clinical Practice - Category: Endocrinology Authors: Source Type: research
Abstract Animal studies indicated that bisphenol A (BPA) exposure during pregnancy may disrupt thyroid function which is critical for fetal development. However, few epidemiological studies have examined this topic and the results were inconsistent. We aimed to evaluate whether prenatal BPA exposure is associated with thyroid hormone levels in Chinese mothers and newborns with stratification by maternal body mass index (BMI). BPA concentration were measured in urine samples collected from 555 women at late pregnancy. Maternal serum free thyroxin (FT4), thyroid-stimulating hormone (TSH) and thyroid peroxidase antib...
Source: Environmental Science and Pollution Research International - Category: Environmental Health Authors: Tags: Environ Sci Pollut Res Int Source Type: research
ConclusionAn attempt of vaginal birth is a reasonable option for short stature women. Maternal height could be included in the selection criteria for planned birth center or home birth.The customized gestational-related optimal weigh could be useful to identify large of gestational age fetus.
Source: European Journal of Obstetrics and Gynecology and Reproductive Biology - Category: OBGYN Source Type: research
This study was conducted with the aim to assess obesity-related adverse maternal, neonatal and perinatal outcomes using new Asian Indian guidelines.MethodologyPregnant women up to 16-week gestation on first visit were enrolled. There were two exposure groups: one with BMI  
Source: The Journal of Obstetrics and Gynecology of India - Category: OBGYN Source Type: research
Publication date: Available online 10 January 2020Source: Mutation Research/Genetic Toxicology and Environmental MutagenesisAuthor(s): Michael Fenech, Nina Holland, Micheline Kirsch-Volders, Lisbeth E. Knudsen, Karl-Heinz Wagner, Helga Stopper, Siegfried Knasmueller, Claudia Bolognesi, Randa El-Zein, Stefano BonassiAbstractThe “Micronuclei and Disease” workshop was organized by the HUMN Project consortium and hosted by the European Environmental Mutagen and Genomics Society at their annual meeting in Rennes, France, on 23 May 2019. The program of the workshop focused on addressing the emerging evidence linking ...
Source: Mutation Research Genetic Toxicology and Environmental Mutagenesis - Category: Genetics & Stem Cells Source Type: research
Source: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy - Category: Endocrinology Tags: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy Source Type: research
AbstractAims/hypothesisObesity during pregnancy increases offspring type 2 diabetes risk. Given that nearly half of women of child-bearing age in many populations are currently overweight/obese, it is key that we improve our understanding of the impact of the in utero/early life environment on offspring islet function. Whilst a number of experimental studies have examined the effect of maternal obesity on offspring islet architecture and/or function, it has not previously been delineated whether these changes are independent of other confounding risk factors such as obesity, postnatal high-fat-feeding and ageing. Thus, we ...
Source: Diabetologia - Category: Endocrinology Source Type: research
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