AI can accurately predict uterine fibroid embolization outcomes

An artificial intelligence (AI) algorithm's analysis of MRI exams performed...Read more on AuntMinnie.comRelated Reading: SIR: UFE bests myomectomy for fibroid treatment Artificial intelligence for MRI distinguishes uterine cancer from fibroids Study finds low reintervention rate for UAE of fibroids Further intervention rates vary after fibroid removal Online patient info about UAE could be better
Source: Headlines - Category: Radiology Source Type: news

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Over the last years, increasing evidence has focused on crucial pathogenetic role of PRL on malignant, premalignant and benign uterine diseases. Studies in animals and humans have documented that PRL receptors (PRL-Rs) are widely expressed on uterine cells and that PRL is directly synthesized by the endometrium under the stimulatory action of progesterone. Uterine PRL secretion is finely modulated by autocrine/paracrine mechanisms which do not depend on the same control factors implied in the regulation of PRL secretion from pituitary. On the other hand, PRL is synthesized also in the myometrium and directly promotes uteri...
Source: Frontiers in Endocrinology - Category: Endocrinology Source Type: research
nis K. Kostakis Several new amino-substituted aza-acridine derivatives bearing a basic side chain have been designed and synthesized. The antiproliferative activity of the target compounds has been evaluated against three cancer cell lines—namely HCT-116 (colorectal), the uterine sarcoma MES-SA, and its doxorubicin-resistant variant MES-SA/Dx5. A limited number of the new acridines showed marginal cytotoxicity against the tested cell lines; nevertheless, these analogues possessed a similar substitution pattern. The moderate biological activity of these derivatives was attributed to their instability in aqueou...
Source: Molecules - Category: Chemistry Authors: Tags: Article Source Type: research
Parity has been reported as a risk factor for cervical cancer. However, no study has investigated the risk of neoplasms of the uterine cervix according to the delivery type. We carried out a retrospective cohort study using nationwide data from the Korean Health Insurance Review and Assessment Database to investigate whether cesarean delivery might be associated with less development of neoplasms of the uterine cervix than a vaginal delivery in women of childbearing age. Women aged 20–44 years, who had undergone vaginal or cesarean deliveries in 2009 were included as subjects. Two individual datasets for carci...
Source: European Journal of Cancer Prevention - Category: Cancer & Oncology Tags: Gynecological cancer Source Type: research
Abstract The health benefits and risks of menopausal hormone therapy among women aged 50-59 years are examined in the Women's Health Initiative randomized, placebo-controlled trials using long-term follow-up data and a parsimonious statistical model that leverages data from older participants to increase precision. These trials enrolled 27,347 healthy post-menopausal women aged 50-79 at 40 U.S. clinical centers during 1993-1998, including 10,739 post-hysterectomy participants in a trial of conjugated equine estrogens, and 16,608 participants with uterus in the trial of these estrogens plus medroxyprogesterone acet...
Source: Am J Epidemiol - Category: Epidemiology Authors: Tags: Am J Epidemiol Source Type: research
Concurrent chemoradiotherapy (CCRT) is the established recommended treatment for patients with locally advanced uterine cervical cancer [1 –4]. However, approximately 30% of cervical cancer patients receiving CCRT will develop local recurrence or distant metastasis [5]. Therefore, early identification of patients at higher risk of disease recurrences might be important for optimizing therapeutic strategies. There are several known pr ognostic factors, including nodal status and tumor size [6,7].
Source: Radiotherapy and Oncology - Category: Radiology Authors: Tags: Original Article Source Type: research
Publication date: Available online 30 September 2020Source: Journal of Molecular StructureAuthor(s): Li Ni, Shu-Li Wang, Jun-Qing Zhao, Gang Wu, Lu-Yan Lang
Source: Journal of Molecular Structure - Category: Molecular Biology Source Type: research
Minimally invasive surgery (MIS) decreases postoperative morbidity after radical hysterectomy (RH) for early-stage cervical cancer. However, a randomized trial and large retrospective data question its safety after observing lower rates of survival than open surgery [1,2]. The causes of this higher recurrence rate are not definitely established but may result from cancer exposure to peritoneum during vaginal section and cancerous-cells spillage enhanced by pneumoperitoneum or uterine manipulator.
Source: The Journal of Minimally Invasive Gynecology - Category: OBGYN Authors: Tags: Video Article Source Type: research
Authors: Li J, Xu W, Zhu Y Abstract Mammaglobin B, also referred to as secretoglobin family 2A member 1 (SCGB2A1), has been reported to be highly expressed in uterine corpus endometrial cancer (UCEC) compared with in the normal endometrium. However, the prognostic value of SCGB2A1 in UCEC remains unclear. The Oncomine, The Cancer Genome Atlas (TCGA) and Clinical Proteomic Tumor Analysis Consortium databases were used to explore the differential expression of SCGB2A1. Furthermore, data of patients with UCEC were downloaded from TCGA, and logistic regression analysis, survival analysis, univariate and multivariate an...
Source: Oncology Letters - Category: Cancer & Oncology Tags: Oncol Lett Source Type: research
For patients with any kind of atypical squamous intraepithelial lesion of the uterine cervix or vagina, colposcopy and punch biopsy are common procedures for histological determination following cytology. Howe...
Source: BMC Cancer - Category: Cancer & Oncology Authors: Tags: Research article Source Type: research
The new Supreme Court nominee believes that a zygote -- the single cell that results from the merger of a sperm cell and an ovum -- is a human being just like you and your Aunt Fannie, and entitled to all of the rights, dignity and respect due accordingly. Can you guess what is wrong with this idea? As I have noted previously, it most certainly does not come from the Bible, not from the Old Testament or any saying ascribed to Jesus or Paul. Nobody actually knew what conception was until the 20th Century, actually, but people knew that pregnancy resulted from sexual intercourse and that it didn't become apparent until ...
Source: Stayin' Alive - Category: American Health Source Type: blogs
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