Cranio-facial mucormycosis —the plastic surgeon’s perspective

ConclusionsWe should maintain a high index of suspicion in cases of necrotizing facial infections. Tissue biopsy will confirm the diagnosis of mucormycosis. A multidisciplinary approach should be applied. The main principles of management would include reversal of immunosuppression or any metabolic disorder, systemic and local antifungal medication, prompt surgical excision of the infected tissues with early aggressive supportive measures, and appropriate reconstruction with rehabilitation. Both prosthetic-based and autologous reconstructions of the resultant defects have been proposed. Choosing either option depends on the surgeon ’s expertise. Prosthesis-based reconstruction provides a relatively accurate esthetic result. As in micro vascular techniques advance and patient demands for a permanent reconstruction increase, more surgeons are trending towards autologous tissue transfer.Level of evidence: Level IV, therapeutic study
Source: European Journal of Plastic Surgery - Category: Cosmetic Surgery Source Type: research

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Authors: Li Y, Gao H, Li Z, Zhang X, Ding Y, Li F Abstract Background: IgG4-related hypophysitis (IgG4-RH) is a rare disease, and its prevalence remains unclear. In recent years, an increasing number of cases have been reported because of the increasing recognition of this disease. We aimed to summarize case reports of IgG4-RH and outline the clinical features and outcomes. Methods: We performed PubMed search of articles using the search terms "hypophysitis [AND] IgG4." Consequently, only 54 English articles (76 cases) met Leporati's diagnostic criteria. Results: Of the 76 cases, the ratio of men ...
Source: International Journal of Endocrinology - Category: Endocrinology Tags: Int J Endocrinol Source Type: research
“I drained the last of my cocktail, gazing up at the ceiling. It was one of those moments that curls the hairs on your neck. At once, the grand scale of this labyrinth of cathedrals became clear, the desert wind blowing through the clever hieroglyphics carved into every available surface. I turned my head back down to ground level just in time to see the man draw back his fist in anger, and then.And then.With a piercing shriek, he lunged straight at my jaw –”Do you ever wake from a dream, marvelling at the inventiveness and detail of your subconscious mind? That disorienting moment where you lie blinking ...
Source: EyeForPharma - Category: Pharmaceuticals Authors: Source Type: news
AbstractHypophysitis (HP) is a rare acute or chronic inflammatory condition of the pituitary gland. The greatest challenge in the management of HP is establishing a diagnosis through clinical criteria and non-invasive methods and predicting the patients ’ clinical outcome. The aim of this review is to describe the neuroradiological findings of this rare disease, providing some information regarding the possible differential diagnosis in order to avoid unnecessary surgery. Gadolinium-enhanced pituitary magnetic resonance imaging (MRI) is considere d the neuroradiological investigation of choice. The features suggestiv...
Source: La Radiologia Medica - Category: Radiology Source Type: research
At the eyeforpharma Awards we strive to reward, support and incentivise innovation, especially when it comes to the value pharma offers patients and customers. We only recognize meaningful innovation which takes our industry, our reputation and our impact forward and the entries are measured objectively by external judges.  I was amazed by the quality of entries this year. With 500 nominations, our judges – a mixture of patients and health professionals – deliberated hard for many hours, finally settling on just 16 winners, each exemplifying the very best work in pharma.   By ‘best’...
Source: EyeForPharma - Category: Pharmaceuticals Authors: Source Type: news
The US recall of recombinant parathyroid hormone Natpara has shone a light on reimbursement issues in the UK and other EU countries, where it's known as Natpar; patients are frustrated.Medscape Medical News
Source: Medscape Medical News Headlines - Category: Consumer Health News Tags: Diabetes & Endocrinology News Source Type: news
CONCLUSIONS: In each case of the coexistence of growth velocity inhibition (not necessarily short stature) with the weight gain (not necessarily obesity) and the appearance of hyperandrogenism and depressive-anxiety disorders, biochemical diagnostics of CS should be performed. Obesi-ty could be a chronic complication of CD in childhood, even after effective neurosurgery treatment. PMID: 31769271 [PubMed - in process]
Source: Pediatric Endocrinology, Diabetes, and Metabolism - Category: Endocrinology Authors: Tags: Pediatr Endocrinol Diabetes Metab Source Type: research
CONCLUSION: Urinary dysfunction is common in Wolfram syndrome, mainly characterized by overactive bladder and urinary retention. The urological risk is major requiring a systelmatic follow-up of these patients. LEVEL OF EVIDENCE: 4. PMID: 31761518 [PubMed - as supplied by publisher]
Source: Progres en Urologie - Category: Urology & Nephrology Tags: Prog Urol Source Type: research
This study presents a case of a 31 year-old man with diabetes, hypertension, rosacea, purple stretch marks and hypokalemia. Findings of diagnostic procedures include high concentrations of cortisol and ACTH, pituitary microadenoma and a tumour in the anterior mediastinum. Dynamic hormone tests determined the source of excess hormone secretion and ectopic ACTH-dependent CS was diagnosed. Due to increasing symptoms of superior vena cava syndrome, an emergency resection of almost the whole tumour was performed, with only a small part of the upper pole left because of the proximity of large vessels and a risk of damaging them....
Source: Medicina (Kaunas) - Category: Universities & Medical Training Authors: Tags: Medicina (Kaunas) Source Type: research
Discussion Holoprosencephaly (HPE) is a clefting problem of the brain. “[HPE] the result of incomplete or absent midline division of the embryonic forebrain into distinct cerebral hemispheres (prosencephalon) between the 18th and 28th day after conception.” There are four distinct subtypes: Alobar – both hemispheres are completely fused and are not separated into the left and right hemispheres. There is agenesis of the corpus callosum, arrhinencephaly and a single ventricle with fused thalami. Facial features are almost always affected. Semilobar – the cerebral hemispheres are fused anteriorly bu...
Source: - Category: Pediatrics Authors: Tags: Uncategorized Source Type: news
We report the case of a 55-year-old diabetic Nigerian woman who presented with typical NL lesions on the lower legs and who responded very well to topical betamethasone dipropionate 0.05% cream. We also briefly review the probable underlying mechanisms leading to the condition and the various treatments that have been found useful.
Source: Nigerian Journal of Clinical Practice - Category: Rural Health Authors: Source Type: research
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