Garmin's Kao donates $20M to create institute within hospital

Garmin Ltd. co-founder and Executive Chairman Min Kao has donated $20 million to a nonprofit Los Angeles hospital. The gift from the Kao Family Foundation will create the Kao Autoimmunity Institute to advance research and treatment of rheumatologic diseases at Cedars-Sinai Medical Center, according to a Tuesday release. The donation also will establish a program within the institute that provides training and education for people with scleroderma, a disease that causes chronic hardening and tightening…
Source: Health Care:Biotechnology headlines - Category: Biotechnology Authors: Source Type: news

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AbstractOptimal wound care is an essential component in the management of systemic sclerosis (SSc) digital ulcers (DUs). DU debridement has been suggested to reduce ulcer-related pain and improve tissue healing. However, only a minority of rheumatologists perform DU debridement, and there is no standard of care/protocol. Our objectives were to (i) evaluate the current evidence for the use of debridement in DU management and (ii) assess whether there are any specific protocols. A systematic literature review was performed searching the PubMed database (between 01/01/1950 –01/03/2019) in accordance with PRISMA guidelin...
Source: Clinical Rheumatology - Category: Rheumatology Source Type: research
To the Editor, Morphea is an autoimmune disease that causes fibrosis of the skin that may result in significant morbidity. Eosinophilic fasciitis (EF) may be considered a deeper form of morphea, and features of both morphea and EF can be present in individual patients. Morphea and EF have been postulated to have pathogenic features that overlap with systemic sclerosis (Laxer and Zulian, 2006). In these diseases, dysregulated immune responses are thought to induce fibrosis (Torok et al., 2019). Treatment of these diseases with non-specific immunosuppressants such as corticosteroids is often ineffective and associated with toxicity.
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: Tags: Letters to the Editor Source Type: research
Systemic sclerosis (SSc) is a rare and severe connective tissue disease combining auto-immune and vasculopathy features, ultimately leading to organ fibrosis. Impaired angiogenesis is an often silent and life-threatening complication of the disease. We hypothesize that CCN3 (NOV), a member of the CCN family of extra-cellular matrix proteins, which is an antagonist of the pro-fibrotic protein CCN2 (CTGF) as well as a pro-angiogenic factor, is implicated in SSc pathophysiology.We performed skin biopsies on 26 SSc patients, both in fibrotic and non-fibrotic areas for 17 patients, and collected 18 healthy control skin specimen...
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: Tags: Original Article Source Type: research
This study confirms the efficacy of autologous stem cell transplantation in real-life practice for severe systemic sclerosis using non myeloablative conditioning. Careful cardio-pulmonary assessment to identify organ involvement at patient referral, reduced cyclophosphamide doses and CD34+ selection may improve outcomes. The study was registered at NCT02516124. PMID: 31949011 [PubMed - as supplied by publisher]
Source: Haematologica - Category: Hematology Authors: Tags: Haematologica Source Type: research
Authors: Eyigor S, Sezgin B, Kuntman BD, Karabulut G, Zihni Yargucu F, Ozturk K, Kirazli T PMID: 31928591 [PubMed - as supplied by publisher]
Source: Clinical and Experimental Rheumatology - Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research
AbstractInterstitial lung disease (ILD) remains a major cause of morbidity and mortality in systemic sclerosis (SSc). Study aim is to characterize and quantify SSc-ILD by using Computer-Aided Lung Informatics for Pathology Evaluation and Rating (CALIPER). Secondly, our objective is to evaluate which radiological pattern is predictive of lung function decline at 12  months follow-up. In the prospective study (IRB 5435), 66 SSc patients underwent high-resolution computerized tomography (HRCT) at baseline. HRCT was performed according to standard protocol using a CT 64GE light speed VCT power scanner. CALIPER classified ...
Source: Clinical Rheumatology - Category: Rheumatology Source Type: research
This study highlights the possible role of NFC as biomarker of AICTD, particularly in SSc and IIM.
Source: Rheumatology International - Category: Rheumatology Source Type: research
Systemic sclerosis (SSc) is a multisystem autoimmune and vascular disease resulting in multiple organ fibrosis [1,2], in which skin fibrosis is caused by the combination of dermal fibroblast activation [3 –6], Th2/Th17-skewed immune polarization [7,8], M2 macrophage differentiation [9], aberrant B cell activation [10,11], increased infiltration of plasmacytoid dendritic cells [12], vascular functional and structural abnormalities [13–16] and epithelial cell activation [17–20]. In particular, im mune cells seem to play a central role because immunosuppressants and/or corticosteroids are mostly effective for skin fibrosis.
Source: Journal of Dermatological Science - Category: Dermatology Authors: Source Type: research
ConclusionsOur results suggest that a combined exercise protocol was feasible for people with lcSSc, with no adverse events,  resulting in high adherence and low attrition rates, high enjoyment levels and intentions for future engagement to this exercise. Thus, the specific protocol is a safe adjunct therapy for people with lcSSc.Trial (NCT number): NCT03058887, February 23, 2017, Points• High-intensity interval training in combination with resistance training constitutes a feasible exercise protocol for peop...
Source: Clinical Rheumatology - Category: Rheumatology Source Type: research
We report an original case of intra- and extra-articular pseudotumoral calcinosis of the wrist diagnosed in a patient followed for mild systemic scleroderma. The calcinosis was revealed in a highly unusual way via ductal syndrome secondary to compression of the radial nerve in the wrist. Surgical treatment resulted in marked clinical and functional improvement. COMMENT: Although subcutaneous calcinoses are a fairly common complication of systemic scleroderma, the pseudo-tumoral form remains extremely rare. It may be complicated by pain, recurrent infection, and functional restriction, but literature contains only very...
Source: Annales de Dermatologie et de Cenereologie - Category: Dermatology Authors: Tags: Ann Dermatol Venereol Source Type: research
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