Increased Smooth Muscle Kv11.1 Channel Expression in Pulmonary Hypertension and Protective Role of Kv11.1 Channel Blocker Dofetilide

Kv11.1 potassium channels are essential for heart repolarization. Prescription medication that blocks Kv11.1 channels lengthens the ventricular action potential and causes cardiac arrhythmias. Surprisingly little is known about the Kv11.1 channel expression and function in the lung tissue. Here we report that Kv11.1 channels were abundantly expressed in the large pulmonary arteries (PAs) of healthy lung tissues from humans and rats. Kv11.1 channel expression was increased in the lungs of humans affected by chronic obstructive pulmonary disease –associated pulmonary hypertension and in the lungs of rats with pulmonary arterial hypertension (PAH).
Source: American Journal of Pathology - Category: Pathology Authors: Tags: Regular article Source Type: research

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ConclusionP. karwinskii leaf extract inhibited reactive oxygen species and exerted an anti-inflammatory effect. Moreover, this extract did not induce gastric damage in the animals. The bioactivity of the species was found to support its traditional use in traditional medicine. This orchid could be used to treat inflammatory diseases without causing the side effects associated with Nonsteroidal anti-inflammatory drugs. It can also be employed to treat other pathological conditions associated with oxidative stress. The findings herein form the basis for the future discovery of natural products that may serve as safe alternat...
Source: Journal of Ethnopharmacology - Category: Drugs & Pharmacology Source Type: research
ConclusionsCMR is a key tool for diagnosing LDAC. Characteristic findings are subepicardial fatty infiltration and midwall-subepicardial late gadolinium enhancement. The prognosis of this population is poor with a high incidence of sudden cardiac death and ventricular arrhythmias.ResumenIntroducción y objetivosRecientemente, la miocardiopatía arritmogénica del ventrículo izquierdo (MCAVI) ha sido reconocida como parte del espectro de la miocardiopatía arritmogénica. Se caracteriza por el reemplazo fibroadiposo de la pared de dicho ventrículo. Se describen las formas de prese...
Source: Revista Espanola de Cardiologia - Category: Cardiology Source Type: research
Authors: Wu YH, Lin JC, Wang TY, Lin TJ, Yen MC, Liu YH, Wu PL, Chen FW, Shih YL, Yeh IJ Abstract Hexavalent chromium [Cr(VI)], is a well‑known toxic form of the heavy metal chromium in the natural environment. Clinical evidence has indicated that exposure to Cr(VI) can cause severe renal damage. The production of reactive oxygen species (ROS) due to intracellular reduction of Cr(VI) is the main mechanism underlying the induction of cellular dysfunction and apoptosis. The present study aimed to investigate in detail the apoptotic pathways induced by Cr(VI)‑exposure in a human immortalized proximal tubular epith...
Source: Molecular Medicine Reports - Category: Molecular Biology Tags: Mol Med Rep Source Type: research
This study identified ANRIL as a critical regulator in HPASMCs induced by hypoxia and demonstrated the potential of gene therapy and drug development for treating PAH. PMID: 31974617 [PubMed - in process]
Source: Molecular Medicine Reports - Category: Molecular Biology Tags: Mol Med Rep Source Type: research
Abstract Kv11.1 potassium channels are essential for heart repolarization. Prescription medication that blocks Kv11.1 channels lengthens the ventricular action potential and causes cardiac arrhythmias. Surprisingly little is known about the Kv11.1 channel expression and function in the lung tissue. Here we report that Kv11.1 channels were abundantly expressed in the large pulmonary arteries (PAs) of healthy lung tissues from humans and rats. Kv11.1 channel expression was increased in the lungs of humans affected by chronic obstructive pulmonary disease-associated pulmonary hypertension and in the lungs of rats wit...
Source: Am J Pathol - Category: Pathology Authors: Tags: Am J Pathol Source Type: research
(Coronary Artery Bypass Grafting) Age and gender: advanced age and female gender have less favourable outcome. Previous cardiovascular events: prior cardiovascular surgery, interventions, myocardial infarction, stroke or transient ischemic attacks. Cardiovascular variables: left ventricular function, hypertension, cardiac arrhythmias. Diabetes mellitus, chronic renal disease, chronic obstructive pulmonary disease. Complexity of disease: number of vessels involved, severity of associated valvular stenosis or regurgitation and endocarditis if any. Hemodynamic status and urgency of surgery. Pulmonary hypertensi...
Source: Cardiophile MD - Category: Cardiology Authors: Tags: Cardiac Surgery Source Type: blogs
Time limit: 0 Quiz-summary 0 of 20 questions completed Questions: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 Information This test series requires login for attempting. You can login easily with your Facebook account (Use the CONNECT WITH icon on the upper part of right sidebar displaying t...
Source: Cardiophile MD - Category: Cardiology Authors: Tags: General Cardiology Source Type: blogs
Chronic Obstructive Pulmonary Disease (COPD) is an entity with high morbidity and mortality worldwide. COPD mortality for 2020 is predicted at third place, second only to ischemic heart disease and cerebrovascular disease (CVD). COPD patients have a higher risk of morbidity and mortality from cardiovascular causes, such as ischemic heart disease, heart failure, peripheral artery disease, diabetes mellitus, depression, thromboembolism, pulmonary hypertension, renal failure, cardiac arrhythmias and obesity.
Source: CVD Prevention and Control - Category: Global & Universal Authors: Tags: Poster Abstract Source Type: research
Please wait while the activity loads. If this activity does not load, try refreshing your browser. Also, this page requires javascript. Please visit using a browser with javascript enabled. If loading fails, click here to try again Click on the 'Start' button to begin the mock test. After answering all questions, click on the 'Get Results' button to display your score and the explanations. There is no time limit for this mock test. Start Congratulations - you have completed DM / DNB Cardiology Entrance Mock Test 9. You scored %%SCORE%% out of %%TOTAL%%. Your performance has been rate...
Source: Cardiophile MD - Category: Cardiology Authors: Tags: Cardiology MCQ DM / DNB Cardiology Entrance Featured Source Type: blogs
Abstract In patients with chronic obstructive pulmonary disease (COPD, defined as a combination of emphysema and chronic bronchitis), sleep quality and architecture are often altered. The very common nocturnal symptoms of cough, dyspnea, chest tightness, and wheezing disturb sleep and lead to daytime dissatisfaction and additional symptoms in these patients. Sleep is often fragmented, while rapid eye movement sleep is generally diminished in duration. Due to nocturnal symptoms and possibly the use of certain medications, some patients with COPD experience difficulty initiating or maintaining sleep, symptoms that d...
Source: Current Respiratory Care Reports - Category: Respiratory Medicine Source Type: research
More News: Arrhythmia | Cardiac Arrhythmia | Cardiology | Chronic Obstructive Pulmonary | Heart | Hypertension | Pathology | Potassium | Pulmonary Hypertension