The effect of methadone, buprenorphine, and shift of methadone to buprenorphine on sperm parameters and antioxidant activity in a male rat model

In conclusion, methadone and buprenorphine enhanced testicular oxidative stress, suppressed blood levels of sexual hormone, including LH, FSH, TT, and FT, and resulted in suppressed sperm parameters. There wer e no significant differences between methadone and buprenorphine treatments in terms of their adverse effects on sperm parameters and antioxidant activity. However, shift of methadone to buprenorphine resulted in the worst adverse effect in the male reproductive system in the rat model.
Source: Comparative Clinical Pathology - Category: Pathology Source Type: research