Treating drug-resistant Candida albicans with 2 natural molecules

(Natural News) Lung moss (Lobaria pulmonaria) contains plant-based compounds with antibiotic and anti-fungal properties. A study from the Shandong University (SDU) tested their efficacy on drug-resistant Candida albicans to identify the most active molecules. The researchers received funding from the National Natural Science Foundation and the SDU’s Young Scholars Program. They published their findings in...
Source: NaturalNews.com - Category: Consumer Health News Source Type: news

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Publication date: 21 January 2020Source: Cell Reports, Volume 30, Issue 3Author(s): Sergio D. Moreno-Velásquez, Su Hlaing Tint, Valentina del Olmo Toledo, Sanda Torsin, Sonakshi De, J. Christian PérezSummaryIntegrating nutrient sensing with the synthesis of complex molecules is a central feature of metabolism. Yet the regulatory mechanisms underlying such integration are often unknown. Here, we establish that the transcription regulators Rtg1/3 are key determinants of sphingolipid homeostasis in the human fungal pathogen Candida albicans. Quantitative analysis of the C. albicans lipidome reveals Rtg1/3-d...
Source: Cell Reports - Category: Cytology Source Type: research
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Source: Journal of Maternal-Fetal and Neonatal Medicine - Category: Perinatology & Neonatology Authors: Source Type: research
In this study, three tribenzoporphyrazines with dendrimeric peripheral substituents were subjected to in vitro antimicrobial photocytotoxicity study. One new magnesium(II) tribenzoporphyrazine with peripheral 3,5-bis(3,5-dimethoxybenzyloxy)benzylsulfanyl substituents was synthesized and subjected to physicochemical characterization using NMR, UV–Vis, and mass spectrometry techniques. In photochemical studies this molecule revealed moderate singlet oxygen generation ability (ΦΔDMF = 0.12, ΦΔDMSO = 0.13). The other two magnesium(II) tribenzoporphyrazines applied in the biological study were ...
Source: Journal of Photochemistry and Photobiology B: Biology - Category: Speech-Language Pathology Source Type: research
by Katherine Lagree, Carol A. Woolford, Manning Y. Huang, Gemma May, C. Joel McManus, Norma V. Solis, Scott G. Filler, Aaron P. Mitchell Metabolic adaptation is linked to the ability of the opportunistic pathogenCandida albicans to colonize and cause infection in diverse host tissues. One way thatC.albicans controls its metabolism is through the glucose repression pathway, where expression of alternative carbon source utilization genes is repressed in the presence of its preferred carbon source, glucose. Here we carry out genetic and gene expression studies that identify transcription factors Mig1 and Mig2 as mediators of...
Source: PLoS Genetics - Category: Genetics & Stem Cells Authors: Source Type: research
AbstractPurpose of ReviewThis review has incorporated the knowledge and experience of the leads of each of the laboratory working parties of the fungal PCR initiative in order to provide up-to-date information on the performance and developments of PCR methods for the detection of fungi that commonly cause invasive fungal disease (IFD).Recent FindingsMolecular diagnosis of IFD enhances the current repertoire of mycological investigations. Providing superior sensitivity and turn-around-time over classical approaches, yet maintaining the benefits of classical tests (e.g. species level identification and identifying resistanc...
Source: Current Fungal Infection Reports - Category: Infectious Diseases Source Type: research
AbstractDue to broad spectrum susceptibility ofCandida species to fluconazole, its convenience as an oral agent, and predictable patient tolerance and safety, current practice guidelines recommend the use of long-term suppression regimens of fluconazole as prophylaxis for recurrent vulvovaginal candidiasis (RVVC), as well as in abbreviated doses when known trigger factors emerge and inevitable symptomatic episodes are predictable. However, recent concerns of fluconazole-resistantCandida albicans strains may impact fluconazole use, particularly, concerns of overuse. This literature review discusses current recommendations f...
Source: Current Infectious Disease Reports - Category: Infectious Diseases Source Type: research
This study aimed to statistically optimize the covalent immobilization of Candida rugosa lipase (CRL) onto a ternary support comprised of OPFL derived nanocellulose (NC) and montmorillonite (MMT) in alginate (ALG) (CRL-ALG/NC/MMT). The coarser topology and the presence of characteristic spherical globules in the field emission scanning electron micrographs and atomic force micrographs, respectively, supported the existence of CRL on ALG/NC/MMT. In addition, amide peaks at 3478 and 1640 cm-1 in the fourier transform infrared spectra affirmed that CRL was covalently bonded to ALG/NC/MMT. The optimized Taguchi Design-a...
Source: Enzyme and Microbial Technology - Category: Biotechnology Source Type: research
Publication date: Available online 17 January 2020Source: Stem Cell ResearchAuthor(s): Kathrin Haake, Tim Wüstefeld, Sylvia Merkert, Doreen Lüttge, Gudrun Göhring, Bernd Auber, Ulrich Baumann, Nico LachmannAbstractChronic mucocutaneous candidiasis (CMC) is a disease that is characterized by susceptibility to chronic or recurrent infections with Candida spp. due to mutations affecting mainly the IL17 signaling of T-Cells. The most common etiologies of CMC are gain-of-function (GOF) mutations in the STAT1 gene. In this paper we report the generation of a hiPSC line from a patient suffering from CMC due to a he...
Source: Stem Cell Research - Category: Stem Cells Source Type: research
; Luiz Chambo Ricardo Miguel Costa de Freitas Berenice Bilharinho Mendonca Ana O. Hoff Madson Q. Almeida Isabel Weigand Matthias Kroiss Maria Claudia Nogueira Zerbini Maria Candida Barisson Villares Fragoso Adrenocortical carcinoma (ACC) is a rare endocrine malignancy with an unfavorable prognosis. Despite the poor prognosis in the majority of patients, no improvements in treatment strategies have been achieved. Therefore, the discovery of new prognostic biomarkers is of enormous interest. Sterol-O-acyl transferase 1 (SOAT1) is involved in cholesterol esterification and lipid droplet formation. Recently...
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Article Source Type: research
ConclusionsSH0.25% demonstrated potential for Candida spp. control in denture wearers with DS. The other protocols showed intermediate activity and might be more suitable for longer immersion periods.
Source: The Journal of Prosthetic Dentistry - Category: Dentistry Source Type: research
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