Diagnosis of pulmonary hypertension by noninvasive methods in hematopoietic cell transplant patients with myelofibrosis

Bone Marrow Transplantation, Published online: 12 December 2019; doi:10.1038/s41409-019-0769-9Diagnosis of pulmonary hypertension by noninvasive methods in hematopoietic cell transplant patients with myelofibrosis
Source: Bone Marrow Transplantation - Category: Hematology Authors: Source Type: research

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Abstract Pulmonary hypertension (PH) is a multi-cellular disease with a high mortality rate. Amongst many cell-types, hematopoietic stem cells (HSCs) are incriminated in the pathogenesis of PH. However, our understanding of the mechanisms that increase HSCs in hypertensive animals or patients remains elusive. Studies suggest that glycolysis is critical for the growth of HSCs. In various cell-types from hypertensive lungs of animals and patients, glycolysis and the glucose-6-phosphate dehydrogenase (G6PD) activity are increased. Herein, we demonstrated in mice that hypoxia increased HSCs in bone marrow and blood, a...
Source: American Journal of Physiology. Lung Cellular and Molecular Physiology - Category: Cytology Authors: Tags: Am J Physiol Lung Cell Mol Physiol Source Type: research
We report here a series of children who developed pulmonary hypertension after HSCT. Methods Between January 2008 and December 2015, we retrospectively analysed 366 children who underwent HSCT (age range 0.5–252 months; median 20.3 months). During the post-HSCT course, echocardiography scans motivated by respiratory symptoms identified 31 patients with elevated tricuspid regurgitation velocity (>2.8 m·s–1), confirmed when possible by right heart catheterisation (RHC). Results 22 patients had confirmed pulmonary hypertension with mean±sd pulmonary arterial pressure 40.1±1...
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Pulmonary vascular disease, Paediatric pulmonology Original Articles: Pulmonary hypertension and paediatrics Source Type: research
Bone Marrow Transplantation, Published online: 06 November 2019; doi:10.1038/s41409-019-0741-8Pulmonary hypertension is associated with increased nonrelapse mortality after allogeneic hematopoietic cell transplantation for myelofibrosis
Source: Bone Marrow Transplantation - Category: Hematology Authors: Source Type: research
Conclusions: The BM plays an important role in the development of PAH. We have shown that the susceptibility to PAH in the BMPR2+/- mouse can be conferred on a wild type animal by BM transplantation and that the BMPR2+/- mouse can be protected from the development of PAH by bone marrow transplantation with WT BM. Further elucidation of the role of the BM is required, but may point to a potential future therapeutic strategy in PAH.
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Pulmonary Circulation and Pulmonary Vascular Disease Source Type: research
Conclusions: These results indicate that TAFIa could be a novel biomarker and realistic therapeutic target of CTEPH. PMID: 28289017 [PubMed - as supplied by publisher]
Source: Circulation Research - Category: Cardiology Authors: Tags: Circ Res Source Type: research
Fitzhugh
Source: Bone Marrow Transplantation - Category: Hematology Authors: Source Type: research
This article reviews PH associated with hematological disorders and its mechanism; and iron homeostasis and its relevance to PH. PMID: 28070238 [PubMed - in process]
Source: World Journal of Cardiology - Category: Cardiology Authors: Tags: World J Cardiol Source Type: research
An organ transplant is a life-changing event extending far beyond the operating room, the clinics and the hospital walls. Read about five children, one young adult and their families, whose lives were forever changed by the Pediatric Transplant Center at Boston Children’s Hospital. Lydia’s liver transplant, a mom’s gift Dawn Cavanagh gave her daughter life twice — first when she was born and, again, when she gave 13-year-old Lydia a piece of her liver last summer. The donor-approval process, which occurs with Boston Children’s partner Lahey Hospital &Medical Center, required hours of...
Source: Thrive, Children's Hospital Boston - Category: Pediatrics Authors: Tags: Our Patients’ Stories double lung transplant ECMO heart failure heart transplant Heart transplant program heart-lung transplant Heung Bae Kim Intestine and Multivisceral Transplant Program Khashayar Vakili kidney transplant Kidney Source Type: news
Background Pulmonary hypertension (PH), a common clinical problem characterized by increased pulmonary artery (PA) pressure, is frequently triggered by hypoxia. Key mediators of cellular hypoxia responses are hypoxia-inducible factors (HIF)-1 and -2, the activity of which is regulated by prolyl-4-hydroxylase domain (PHD) proteins, with PHD2 being the main oxygen sensor that controls HIF activity under normoxia. Although both transcription factors are expressed in the lung, little is known about their cell type-specific roles in the pathogenesis of PH. Methods and Results Here we used a genetic approach to investigate the ...
Source: Journal of Investigative Medicine - Category: Research Authors: Tags: Pulmonary/Critical Care Source Type: research
avies, S Jodele &C E Dandoy
Source: Bone Marrow Transplantation - Category: Hematology Authors: Source Type: research
More News: Bone Marrow Transplant | Hematology | Hypertension | Pulmonary Hypertension | Transplants