Initial Immune Response in Escherichia coli , Staphylococcus aureus , and Candida albicans Bacteremia

AbstractSepsis remains a leading cause of mortality worldwide and is characterized by sustained inflammatory responses, reflected as changes in the expression profile of cytokines with time. The aim of the present study was to investigate the dynamic changes in complete blood count, serum chemistry, procalcitonin (PCT), tumor necrosis factor-alpha (TNF- α), and interleukin-6 (IL-6) inEscherichia coli,Staphylococcus aureus, andCandida albicans bacteremia. Study subjects were 32 healthy male Landrace-Large White pigs, aged 10 –15 weeks and of average weight 19 ± 2 kg. Bacteremia was induced by continuous intravenous infusion of microbial suspensions during a period of 8 h.E. coli andS. aureus bacteremia were associated with a significant gradual decrease in white blood cells and platelets, respectively (p = 0.002 andp = 0.004), while candidemia was characterized by a significant gradual decrease in lymphocytes (p = 0.009). Serum PCT levels were either undetectable or very low, with no significant changes with time in all groups.E. coli bacteremia elicited a strong pro-inflammatory response, characterized by a significant increase in TNF-α expression from the onset of bacteremia (p = 0.042).C. albicans exhibited a different profile with an early, moderate increase in TNF-α followed by a subsequent marked increase in IL-6 levels (p = 0.03). The differential regulation of inflammatory and hematological responses depending on the pathogenic agent can ...
Source: Inflammation - Category: Allergy & Immunology Source Type: research

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In this study, three tribenzoporphyrazines with dendrimeric peripheral substituents were subjected to in vitro antimicrobial photocytotoxicity study. One new magnesium(II) tribenzoporphyrazine with peripheral 3,5-bis(3,5-dimethoxybenzyloxy)benzylsulfanyl substituents was synthesized and subjected to physicochemical characterization using NMR, UV–Vis, and mass spectrometry techniques. In photochemical studies this molecule revealed moderate singlet oxygen generation ability (ΦΔDMF = 0.12, ΦΔDMSO = 0.13). The other two magnesium(II) tribenzoporphyrazines applied in the biological study were ...
Source: Journal of Photochemistry and Photobiology B: Biology - Category: Speech-Language Pathology Source Type: research
r Marutescu Limban In a drug-repurposing-driven approach for speeding up the development of novel antimicrobial agents, this paper presents for the first time in the scientific literature the synthesis, physico-chemical characterization, in silico analysis, antimicrobial activity against bacterial and fungal strains in planktonic and biofilm growth state, as well as the in vitro cytotoxicity of some new 6,11-dihydrodibenz[b,e]oxepin-11(6H)one O-(arylcarbamoyl)oximes. The structures of intermediary and final substances (compounds 7a–j) were confirmed by 1H-NMR, 13C-NMR and IR spectra, as well as by eleme...
Source: Molecules - Category: Chemistry Authors: Tags: Article Source Type: research
Publication date: Available online 11 January 2020Source: Journal of Molecular StructureAuthor(s): R. Kalarani, M. Sankarganesh, G.G. Vinoth Kumar, M. KalanithiAbstractIn this article, synthesis of Co(II), Cu(II) and Zn(II) complexes of bidentate Schiff base ligand (L) 2-((1H-Benzo [d]imidazole-4ylimmino) methyl phenol is presented here. The Schiff base and its metal (II) complexes were characterized by micro analysis and spectral techniques such as AAS, UV–Vis, FT-IR, NMR, molar conductance and magnetic moment measurements. Molar conductance reveals the non electrolytic nature of the complexes. From the analytical a...
Source: Journal of Molecular Structure - Category: Molecular Biology Source Type: research
Publication date: April 2020Source: Materials Science and Engineering: C, Volume 109Author(s): Simona Morariu, Maria Bercea, Luiza Madalina Gradinaru, Irina Rosca, Mihaela AvadaneiAbstractPhysical poly(vinyl alcohol) (PVA) hydrogels containing up to 3% Laponite RD (LRD) were obtained by freezing/thawing method. The structure and the morphology of PVA/LRD hydrogels were evaluated by ATR-FTIR and SEM measurements, respectively. The morphological analysis of the hydrogels revealed the formation of clay agglomerates and large size aggregates at LRD concentrations above 2.5%. The rheological and mechanical properties of the PVA...
Source: Materials Science and Engineering: C - Category: Materials Science Source Type: research
Publication date: Available online 8 January 2020Source: Microbial PathogenesisAuthor(s): Raju Rajasabapathy, Sanjeev C. Ghadi, Balakrishnan Manikandan, Chellandi Mohandass, Akhila Surendran, Syed G. Dastager, Ram M. Meena, Rathinam Arthur JamesAbstractCulturable bacteria associated with marine sponges and coral mucus (collected from Gulf of Mannar and Palk Bay) were screened for their prospective antimicrobial compounds against 9 bacterial pathogens (Bacillus megaterium, B. cereus, Salmonella typhimurium, Staphylococcus aureus, Proteus vulgaris, Klebsillla pneumoniae, Escherichia coli, Pseudomonas aeruginosa and Acinetoba...
Source: Microbial Pathogenesis - Category: Infectious Diseases Source Type: research
Authors: Żarowska B, Koźlecki T, Piegza M, Jaros-Koźlecka K, Robak M Abstract The progress of research on silver nanoparticles (AgNPs) has led to their inclusion in many consumer products (chemicals, cosmetics, clothing, water filters, and medical devices) as a biocide. Despite the widespread use of AgNPs, their biocidal activity is not yet fully understood and is usually associated with various factors (size, composition, surface, red-ox potential, and concentration) and, obviously, specific features of microorganisms. There are merely a few studies concerning the interaction of molds with AgNPs. Therefore, the...
Source: Polish Journal of Microbiology - Category: Microbiology Tags: Pol J Microbiol Source Type: research
Publication date: Available online 27 December 2019Source: Inorganica Chimica ActaAuthor(s): Joshua A. Obaleye, Abiodun A. Ajibola, Van B. Bernardus, Eric C. Hosten, Andrew OzarowskiAbstractIn this work, we report the synthesis and characterization of a novel dimeric complex Cu2(μ–TCA)2(TCA)2(MET)4 [where TCA = trichloroacetic acid; MET = metronidazole]. The reaction was carried out at room temperature to obtain a blue crystalline compound. The complex was characterized by elemental analysis, electronic spectroscopy, FT–IR, High–Field EPR and X–ray crystallography. The complex crystallized in the...
Source: Inorganica Chimica Acta - Category: Chemistry Source Type: research
Publication date: Available online 26 December 2019Source: Food BioscienceAuthor(s): Seyedeh-Maryam Hasheminya, Jalal DehghannyaAbstractChemical compounds, total phenolic content, antioxidant and antimicrobial activity of Pistacia atlantica subsp. kurdica hulls’ essential oil (EO) was investigated. The EO was extracted using hydrodistillation and its GC-MS analysis showed 95 compounds, the most important of which were α-pinene (10.8%), β-citral (7.0%), carvone hydrate (4.4%), myristic acid (4.9%), p-acetyltoluene (3.5%), pinocarveol (3.3%) and palustrol (3.3%). Total phenolic compounds in the EO was 178 ...
Source: Food Bioscience - Category: Food Science Source Type: research
o Albericio Novel thiazolidine-2,4-dione carboxamide and amino acid derivatives were synthesized in excellent yield using OxymaPure/N,N′-diisopropylcarbodimide coupling methodology and were characterized by chromatographic and spectrometric methods, and elemental analysis. The antimicrobial and antifungal activity of these derivatives was evaluated against two Gram-positive bacteria (Staphylococcus aureus and Bacillus subtilis), two-Gram negative bacteria (Escherichia coli and Pseudomonas aeruginosa), and one fungal isolate (Candida albicans). Interestingly, several samples demonstrated weak to moderate antib...
Source: Molecules - Category: Chemistry Authors: Tags: Article Source Type: research
Publication date: December 2019Source: Chinese Journal of Natural Medicines, Volume 17, Issue 12Author(s): Jie ZHANG, Chuan-Xi WANG, Xiao-Jun SONG, Shuang LI, Huan ZHAO, Guo-Dong CHEN, Dan HU, Hao GAO, Xin-Sheng YAOAbstractA pair of new tirucallane triterpenoid epimers, picraquassins M and N (1> and 2), were isolated from the stems of Picrasma quassioides (D. Don) Benn. Their structures were determined based on comprehensive spectroscopic and X-ray crystallographic analyses. In addition, their AChE inhibitory activity, cytotoxicity against five human tumour cell lines (SW480, MCF-7, HepG2, Hela, and PANC-1), and antimic...
Source: Chinese Journal of Natural Medicines - Category: Complementary Medicine Source Type: research
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