Nanoparticle ‐Embedded Electrospun Fiber–Covered Stent to Assist Intraluminal Photodynamic Treatment of Oesophageal Cancer

Electrospun fiber –covered stents as a nanoparticle delivery platform of photodynamic therapy (PDT) to assist orthotopic esophageal tumor therapy are proposed. The hypoxic microenvironment can be alleviated by the reaction of manganese dioxide in the fibers with tumor endogenous hydrogen peroxide. The functional fi ber‐covered stents can effectively exert the PDT effect as a noninvasive method for patients with advanced‐stage esophageal cancer. AbstractDrug ‐eluting stents (DESs) are promising candidates for treating human oesophageal cancer. However, the use of DESs to assist photodynamic therapy (PDT) of orthotopic oesophageal tumors is not yet demonstrated to the best of current knowledge. Herein, through an electrospinning technology it is shown that oxygen‐producing manganese dioxide nanoparticles are embedded into elelctrospun fibers, which are subsequently covered onto stents. Upon implantation, the nanoparticles are gradually released from the fibers and then diffuse into the nearby tumor tissue. Then, the hypoxic microenvironment can be effectively alleviated by reaction of MnO2 with the endogenous H2O2 within the tumor. After demonstrating the excellent PDT efficacy of the stents in a conventional subcutaneous mouse tumor model, such stents are further used for PDT treatment in a rabbit orthotopic oesophageal cancer model by inserting an optical fiber into the tumor site. Greatly prolonged survival of rabbits is observed after such intraluminal PDT treatme...
Source: Small - Category: Nanotechnology Authors: Tags: Communication Source Type: research