"Energy-sensing pathways in ischemia: The counterbalance between AMPK and mTORC".

"Energy-sensing pathways in ischemia: The counterbalance between AMPK and mTORC". Curr Pharm Des. 2019 Dec 10;: Authors: Cespedes A, Villa M, Benito-Cuesta I, Perez-Alvarez MJ, Ordoñez L, Wandosell F Abstract Stroke is an important cause of death and disability, and it is the second leading cause of death worldwide. In humans, middle cerebral artery occlusion (MCAO) is the most common cause of ischemic stroke. The damage corresponds in itself to the sum of the lack of nutrients and oxygen contributed by the blood flow. The present review aims to analyze to what extent the lack of each of the elements of the system produce damage and in which mechanisms are unchained by this deficiency. We believe that the specific analysis of what the lack of each component means could give light to new therapeutic targets for this important brain pathology. PMID: 31820693 [PubMed - as supplied by publisher]
Source: Current Pharmaceutical Design - Category: Drugs & Pharmacology Authors: Tags: Curr Pharm Des Source Type: research