Understanding the global tuberculosis epidemic: moving towards routine whole-genome sequencing

Source: International Journal of Tuberculosis and Lung Disease - Category: Respiratory Medicine Authors: Tags: EDITORIALS Source Type: research

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ConclusionsIn this study, the prevalence of Hr-TB among TB patients was higher than the prevalence of rifampicin resistance globally. Many patients with Hr-TB would be missed by current diagnostic algorithms driven by rifampicin testing, highlighting the need for new rapid molecular technologies to ensure access to appropriate treatment and care. The low prevalence of resistance to pyrazinamide and fluoroquinolones among patients with Hr-TB provides further justification for the recommended modified treatment regimen.
Source: PLoS Medicine - Category: Internal Medicine Authors: Source Type: research
The global control of tuberculosis (TB) remains a major challenge due to the epidemic of drug-resistant tuberculosis, especially multidrug-resistant tuberculosis (MDR-TB), which is resistant to rifampin and isoniazid (Zhao et al., 2012; Zhang et al., 2014b). According to recent WHO global estimates, there were 480,000 MDR-TB cases in 2017 (WHO,2018). Almost half of the global MDR-TB cases occurred in China and India (WHO,2018). Due to resistance to both of the most effective antituberculosis drugs, the treatment of MDR-TB requires the use of the less effective and more toxic second-line drugs; approximately half of MDR-TB ...
Source: International Journal of Infectious Diseases - Category: Infectious Diseases Authors: Source Type: research
For the past decade, the epidemic of multidrug resistance tuberculosis (MDR-TB) stays high in China. We investigated the possible driving forces behind the epidemics from phylogenetic and historical perspectives.
Source: Journal of Infection - Category: Infectious Diseases Authors: Source Type: research
Authors: Sabbatani S, Fiorino S, Manfredi R Abstract During the Great War, which involved Italy from May 1915 until November 1918, the Italian Army paid an extremely high price in terms of suffering; around 600,000 soldiers died. About 100,000 of these deaths were caused by diseases, mainly infectious ones. The casualties accounted for over one million cases. Epidemics of cholera and petechial typhus were recorded as well as an increase in morbidity due to tuberculosis and malaria, which had shown some minor epidemiological reduction in several regions of Italy during the years preceding the Great War. A large numb...
Source: Infezioni in Medicina - Category: Infectious Diseases Tags: Infez Med Source Type: research
[The Conversation Africa] The infectious disease burden in Africa is very high, particularly for tuberculosis (TB), malaria and HIV/AIDS. In 2018, nearly a quarter (24%) of TB cases in the world were in Africa. The region accounted for 93% of malaria cases. The continent also bears the brunt of the HIV epidemic: 20.6 million of the 37.9 million people living with HIV are in eastern and southern Africa.
Source: AllAfrica News: HIV-Aids and STDs - Category: Infectious Diseases Source Type: news
The bidirectional relationship between the twin epidemics of Tuberculosis (TB) and Human Immunodeficiency Virus (HIV) causes major global health challenges in the twenty-first century. TB-HIV co-infected peopl...
Source: BMC Public Health - Category: Consumer Health News Authors: Tags: Research article Source Type: research
Abstract Albania is a Balkan country with moderate to low incidence of tuberculosis (TB) and very low prevalence of drug resistant TB. Here, we analyzed a country-wide multi-year Mycobacterium tuberculosis collection in order to detect possible dynamic trends of TB in Albania, with a focus on drug resistance and endemic/epidemic clones. In total, 743 isolates collected in 2007 to 2011 were divided into 107 spoligotypes and 351 MIRU-types. Based on the MIRU-VNTR phylogenetic analysis, the isolates were assigned to the following lineages/families: animal ecotypes (5 M. bovis and 2 M. caprae isolates), Lineage 2 ...
Source: Infection, Genetics and Evolution - Category: Genetics & Stem Cells Authors: Tags: Infect Genet Evol Source Type: research
By SAURABH JHA, MD Slumdog TB No one knows who gave Rahul Roy tuberculosis. Roy’s charmed life as a successful trader involved traveling in his Mercedes C class between his apartment on the plush Nepean Sea Road in South Mumbai and offices in Bombay Stock Exchange. He cared little for Mumbai’s weather. He seldom rolled down his car windows – his ambient atmosphere, optimized for his comfort, rarely changed. Historically TB, or “consumption” as it was known, was a Bohemian malady; the chronic suffering produced a rhapsody which produced fine art. TB was fashionable in Victorian Britain...
Source: The Health Care Blog - Category: Consumer Health News Authors: Tags: Artificial Intelligence Health Tech Saurabh Jha TB tuberculosis Source Type: blogs
ConclusionGains can be attained by targeting DM individuals with interventions to reduce TB burden. Most strategies were effective with
Source: Epidemics - Category: Epidemiology Source Type: research
Publication date: Available online 20 November 2019Source: Academic RadiologyAuthor(s): Sagar Kulkarni, Saurabh JhaTuberculosis is a leading cause of death from infectious disease worldwide, and is an epidemic in many developing nations. Countries where the disease is common also tend to have poor access to medical care, including diagnostic tests. Recent advancements in artificial intelligence may help to bridge this gap. In this article, we review the applications of artificial intelligence in the diagnosis of tuberculosis using chest radiography, covering simple computer-aided diagnosis systems to more advanced deep lea...
Source: Academic Radiology - Category: Radiology Source Type: research
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