Re: Screening for cytomegalovirus infection in pregnancy

Source: BMJ Comments - Category: General Medicine Source Type: forums

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Maternal cytomegalovirus (CMV) infection and/or reactivation in pregnancy is associated with a myriad of adverse infant outcomes. However, the role of host genetic polymorphisms in modulating maternal CMV stat...
Source: BMC Medical Genetics - Category: Genetics & Stem Cells Authors: Tags: Research article Source Type: research
CONCLUSIONS: Routine ultrasound screening in pregnancy is not an appropriate screening tool for congenital CMV infection leading to long-term sequelae, contrasting with the high performance of targeted prenatal imaging in known cases of fetal infections. Non-specific nature of ultrasound features and their evolution and lack of awareness of caregivers about cCMV are the main explanations. Sonologists' awareness and knowledge of maternal serological status in the first trimester seem key to the performance of routine prenatal ultrasound. This article is protected by copyright. All rights reserved. PMID: 32339337 [PubMe...
Source: The Ultrasound Review of Obstetrics and Gynecology - Category: Radiology Authors: Tags: Ultrasound Obstet Gynecol Source Type: research
Acute chorioamnionitis is characterized by neutrophilic infiltration and inflammation at the maternal fetal interface. It is a relatively common complication of pregnancy and can have devastating consequences including preterm labor, maternal infections, fetal infection/inflammation, fetal lung, brain, and gastrointestinal tract injury. In this review, we will discuss current understanding of the pathogenesis, immunobiology, and mechanisms of this condition. Most commonly, acute chorioamnionitis is a result of ascending infection with relatively low-virulence organisms such as the Ureaplasma species. Furthermore, recent va...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
AbstractCongenital infections affecting newborn infants can have potentially devastating clinical outcomes. They are usually caused by viruses that infect mothers during pregnancy and are transmitted to the fetus or newborn during the prenatal, perinatal or postnatal periods. Congenital cytomegalovirus (cCMV) is the most common congenital infection affecting up to 2.5% of all live births. Even though most infected infants are asymptomatic at birth, cCMV is an important cause of neurodevelopmental impairment and represents the main cause of non-hereditary sensorineural hearing loss. Also, congenital Zika infection has emerg...
Source: Indian Journal of Pediatrics - Category: Pediatrics Source Type: research
Abstract Congenital infections refer to a group of perinatal infections that may have similar clinical presentations, including rash and ocular findings. TORCH is the acronym that covers these infections (toxoplasmosis, other [syphilis], rubella, cytomegalovirus, herpes simplex virus). There are, however, other important causes of intrauterine/perinatal infections, including enteroviruses, varicella zoster virus, Zika virus, and parvovirus B19. Intrauterine and perinatal infections are significant causes of fetal and neonatal mortality and important contributors to childhood morbidity. A high index of suspicion fo...
Source: Hong Kong Med J - Category: General Medicine Authors: Tags: Hong Kong Med J Source Type: research
Abstract Intrauterine infections with the pathogens, including toxoplasmosis, other (syphilis, varicella, mumps, parvovirus, and HIV), rubella, cytomegalovirus, and herpes simplex (TORCH) in susceptible individuals during pregnancy, result in microcephaly, white matter disease, cerebral atrophy, and calcifications in the fetus. Pseudo-TORCH syndrome is an umbrella term, consisting of several syndromes, resultant from different genetic alterations and pathogenetic mechanisms. Band-like calcification with simplified gyration and polymicrogyria (BLC-PMG) is one of these conditions, resultant from biallelic mutations ...
Source: European Journal of Medical Genetics - Category: Genetics & Stem Cells Authors: Tags: Eur J Med Genet Source Type: research
We report a case of nonprimary CMV infection in pregnancy with fetal neurological alterations. A positive quantitative polymerase chain reaction in amniotic fluid (AF) confirmed the diagnosis of cCMV infection that triggered a voluntary termination of pregnancy. Quantitative polymerase chain reaction assays of AF are used to confirm a fetal cCMV infection, and the invasive amniocentesis procedure is justified when abnormalities are found in ultrasound control, although they are not validated to use in AF.
Source: Infectious Diseases in Clinical Practice - Category: Infectious Diseases Tags: Case Reports Source Type: research
Abstract Congenital cytomegalovirus (CMV) infection is the most common non-genetic cause of hearing loss and neurological disorder in children. Its overall prevalence is approximately 0.5% in Europe. In France, systematic screening during pregnancy is not recommended; screening is performed only if there are maternal or fetal symptoms suggestive of this infection. Approximately 90% of infected newborns are asymptomatic at birth, and among them the risk of neurosensory sequelae is 5-15%. By contrast, the prevalence of neurosensory impairment in symptomatic newborns at birth varies from 17% to 60%. Congenital CMV in...
Source: Archives de Pediatrie - Category: Pediatrics Authors: Tags: Arch Pediatr Source Type: research
(Kobe University) A group led by researchers from Kobe University has illuminated clinical factors that are related to the occurrence of congenital cytomegalovirus (CMV) infection in newborns. They revealed that fever or cold-like symptoms during pregnancy, and threatened miscarriage or threatened premature labor in the second trimester were associated with CMV infection in newborns.
Source: EurekAlert! - Infectious and Emerging Diseases - Category: Infectious Diseases Source Type: news
Cytomegalovirus is the most common congenital infection, affecting 0.5-2% of all live births and the main non-genetic cause of congenital sensorineural hearing loss and neurological damage. Congenital CMV can follow maternal primary infection or non-primary infection. Sensori-neurological morbidity is confined to the first trimester with up to 40-50% of infected neonates developing sequelae after first trimester primary infection. Serological testing before 14 weeks is critical to identify primary infection within three months around conception but is not informative in women already immune before pregnancy.
Source: American Journal of Obstetrics and Gynecology - Category: OBGYN Authors: Tags: Expert Review Source Type: research
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