Genetic instability as a driver for immune surveillance

ConclusionsThese two main results indicate a potential role of genetic instability as a driver of transitions towards immune control of tumors, as well as the effectiveness of increasing mutational loads prior to adoptive cell therapies. This mathematical framework is therefore a quantitative step towards predicting the outcomes of combined therapies where genetic instability might play a key role.
Source: Journal for Immunotherapy of Cancer - Category: Cancer & Oncology Source Type: research