Acute severe radiation pneumonitis among non-small cell lung cancer (NSCLC) patients with moderate pulmonary dysfunction receiving definitive concurrent chemoradiotherapy: Impact of pre-treatment pulmonary function parameters

ConclusionThe DLCO% and MLD may predict the risk for SARP among patients with pre-treatment moderate pulmonary dysfunction who receive dCCRT for NSCLC. Prospective studies are needed to validate our findings.
Source: Strahlentherapie und Onkologie - Category: Cancer & Oncology Source Type: research

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This study aims to evaluate the impact of diffusing capacity of the lung for carbon monoxide (DLco) before and after neoadjuvant concurrent chemoradiotherapy (CCRT) on postoperative pulmonary complication (PPC...
Source: Respiratory Research - Category: Respiratory Medicine Authors: Tags: Research Source Type: research
This study aims to evaluate the impact of diffusing capacity of the lung for carbon monoxide (DLco) before and after neoadjuvant concurrent chemoradiotherapy (CCRT) on postoperative pulmonary complication (PPC) among stage IIIA/N2 non-small-cell lung cancer (NSCLC) patients. METHODS: We retrospectively studied 324 patients with stage IIIA/N2 NSCLC between 2009 and 2016. Patients were classified into 4 groups according to DLco before and after neoadjuvant CCRT; normal-to-normal (NN), normal-to-low (NL), low-to-low (LL), and low-to-very low (LVL). Low DLco and very low DLco were defined as DLco
Source: Respiratory Care - Category: Respiratory Medicine Authors: Tags: Respir Res Source Type: research
ConclusionPatients with a V20total lung 
Source: Thoracic Cancer - Category: Cancer & Oncology Authors: Tags: ORIGINAL ARTICLE Source Type: research
Introduction: Chemotherapy has negativ effect on pulmonary function parameters (PFP), which are main criteria in preoperative assessment for surgery in patients suffer from non-small cell lung cancer (NSCLC).Aim: The aim of the study was to determine effect of neoadjuvant chemotherapy (NACT) on PFP and postoperative complications in patients undergoing surgery for NSCLC.Methods: The study was designed as cohort study. In the study was included patients with patohistologically proven NSCLC that were initially or after NACT in resectable IIIA stage of disease. The first group of patients were treated with NACT (four cycles g...
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Clinical respiratory physiology, exercise and functional imaging Source Type: research
AbstractPurposeTo evaluate alterations in pulmonary function indices after helical tomotherapy and explore potential associations with biologically corrected dosimetric parameters.Patients and methodsIn 64  patients with inoperable locally advanced non-small cell lung cancer, pulmonary function tests before and within 6 months after radiotherapy were evaluated retrospectively. In the case of concurrent chemotherapy a total dose of 67.2 Gy was delivered, otherwise 70.5 Gy was provided. In 44 pa tients, late pulmonary function changes (≥6 months after radiotherapy) could also be assessed.Resul...
Source: Strahlentherapie und Onkologie - Category: Cancer & Oncology Source Type: research
This study hypothesized that similar VOCs might be detected after HBOT. Methods: Ten healthy volunteers of the Royal Netherlands Navy underwent six HBOT sessions (95 min at 253 kPa, including three 5-min “air breaks”), i.e., on five consecutive days followed by another session after 2 days of rest. At 30 min before the dive, and at 30 min, 2 and 4 h post-dive, exhaled breath was collected and followed by PFT. Exhaled breath samples were analyzed using gas chromatography-mass spectrometry (GC-MS). After univariate tests and correlation of retention times, ion fragments could be identified using a reference data...
Source: Frontiers in Physiology - Category: Physiology Source Type: research
Conclusions: Active treatment should be considered in GAP stage I. Meanwhile, no beneficial therapeutic modalities were found for high GAP stage; the performance status and lung cancer stage should be considered when deciding for the necessity of surgery for patients in this stage.
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Lung Cancer Source Type: research
CONCLUSIONS: CORM-2 modulates biological functions of NSCLC cells and may provide a novel therapeutic strategy for lung cancer. PMID: 29687848 [PubMed - in process]
Source: European Review for Medical and Pharmacological Sciences - Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research
Authors: Jeon YJ, Choi YS, Lee KJ, Lee SH, Pyo H, Choi JY Abstract Background: We evaluated the feasibility and outcomes of pulmonary resection and mediastinal node dissection (MND) by video-assisted thoracoscopic surgery (VATS) following neoadjuvant therapy for stage IIIA N2 non-small cell lung cancer (NSCLC). Methods: From November 2009 to December 2013, a total of 35 consecutive patients with pathologically or radiologically confirmed stage IIIA N2 lung cancer underwent pulmonary resection and MND, performed by a single surgeon, following neoadjuvant chemoradiation. Preoperative patient characteristics, surg...
Source: Korean Journal of Thoracic and Cardiovascular Surgery - Category: Cardiovascular & Thoracic Surgery Tags: Korean J Thorac Cardiovasc Surg Source Type: research
Conclusions: Quitting smoking at the time of diagnosis leads to improved survival in patients with lung cancer and should be promoted as soon as possible to help improve survival.
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Lung Cancer Source Type: research
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