Adverse effects of subchronic exposure to cooking oil fumes on the gonads and the GPR30-mediated signaling pathway in female rats

ConclusionThis study indicated that cooking oil fume exposure disrupted the estrous cycle, sex hormone patterns, and follicle development in female rats in a dose-dependent manner. These adverse effects of cooking oil fumes on female reproductive health were correlated with the G-protein-coupled receptor 30-mediated signaling pathway.HighlightsSubchronic exposure to COFs for 56 days had gonadal toxicity in female rats, that disrupted the estrous cycle, sex hormone patterns, and follicle development in a dose-dependent manner.Reproductive endocrine disruption might be one of the female gonadotoxicity mechanisms of COFs.These adverse effects of COFs on female reproductive health were correlated with the GPR30-mediated signaling pathway.
Source: Molecular and Cellular Toxicology - Category: Cytology Source Type: research