Inhibition of bromodomain and extra-terminal proteins increases sensitivity to venetoclax in chronic lymphocytic leukaemia.

In this study, we investigated the cooperative role of the BCL2 inhibitor venetoclax and the BRD4 inhibitor JQ1. In particular, we found that JQ1 shows additional activity with venetoclax, in CLL cell lines and in ex vivo isolated primary CD19+ lymphocytes, arguing in favour of combination strategies. Lastly, JQ1 is also effective in venetoclax-resistant CLL cell lines. Together, our findings indicated that the BET inhibitor JQ1 could be a promising therapy in CLL, both as first-line therapy in combination with venetoclax and as second-line therapy, after the emergence of venetoclax-resistant clones.
PMID: 31821686 [PubMed - as supplied by publisher]

Source: J Cell Mol Med - December 9, 2019 Category: Molecular Biology Authors: Carrà G, Nicoli P, Lingua MF, Maffeo B, Cartellà A, Circosta P, Brancaccio M, Parvis G, Gaidano V, Guerrasio A, Saglio G, Taulli R, Morotti A Tags: J Cell Mol Med Source Type: research