Synthesis of luminescent rhodium(III) cyclometalated complex by sp2(C)–S bond activation: Application as catalyst in transfer hydrogenation of ketones and live cell imaging

Publication date: 15 March 2020Source: Journal of Molecular Structure, Volume 1204Author(s): Puspendu Roy, Deblina Sarkar, Paramita Ghosh, Chandan Kumar Manna, Nabendu Murmu, Tapan Kumar MondalAbstractA new fluorescent Rh(III) cyclometalated complex, [Rh(PPh3)2(L)Cl] (1) is synthesized via sp2(C)–S bond activation of a thioether containing azo-phenol ligand (L-SCH2CH3). The pseudo octahedral geometry around rhodium is confirmed by single crystal X-ray diffraction method. Cyclic voltammogram of the complex exhibits a quasi-reversible oxidation couple with E1/2 of 0.74 V (ΔE = 100 mV) along with a quasi-reversible reduction couple (E1/2 = −1.18 V, ΔE = 130 mV) in acetonitrile. The complex exhibits low energy emission band at 682 nm with emission quantum yield (ϕ = 0.103) upon excitation at 583 nm. Cytotoxicity of the complex is studied by MTT method with human breast cancer cell lines and IC50 value is found to 18.5 μM. In presence of the complex (10 μM) a bright red fluorescence image of MCF-7 cell lines is observed under fluorescence microscope. Moreover, the complex acts as effective catalyst towards transfer hydrogenation of ketones.Graphical abstractA new fluorescent Rh(III) cyclometalated complex, [Rh(PPh3)2(L)Cl] (1) has been synthesized via sp2(C)–S bond activation of a thioether containing azo-phenol ligand (L-SCH2CH3). The complex exhibits low energy emission band at 682 nm with high emission quantum yield (ϕ = 0.103). In presence of th...
Source: Journal of Molecular Structure - Category: Molecular Biology Source Type: research