Cardiovascular health and retinal microvascular geometry in Australian 11–12 year-olds

Publication date: Available online 10 December 2019Source: Microvascular ResearchAuthor(s): Mengjiao Liu, Kate Lycett, Melissa Wake, Mingguang He, Jessica A. Kerr, Richard Saffery, Markus Juonala, Tim Olds, Terry Dwyer, David P. Burgner, Tien Yin WongAbstractTraditional retinal microvascular parameters (smaller arteriolar and greater venular caliber) are associated with cardiovascular risk factors, pre-clinical vascular phenotypes and clinical cardiovascular events in adults. Although novel retinal microvascular geometric parameters showed analogous associations in adults, less is known whether these parameters are associated with cardiovascular health from childhood. In a population-based cross-sectional study in children (n = 1126, mean age 11.4 years, 50.3% girls), we examined associations of cardiovascular risk factors and pre-clinical arterial phenotypes with retinal geometric parameters. Cardiovascular parameters included body mass index (BMI), an inflammatory marker (GlycA), low-density lipoprotein and high-density lipoprotein (HDL) cholesterol, systolic (SBP) and diastolic blood pressure, large artery functional (pulse wave velocity, PWV and carotid arterial elasticity) and structural (carotid intima-media thickness) phenotypes. Retinal geometric parameters (fractal dimension (Df) and tortuosity) were quantified from retinal images. Multivariable regression models were performed and adjusted for potential confounders. Higher values for BMI, SBP and PWV showed we...
Source: Microvascular Research - Category: Biochemistry Source Type: research