A typical carcinoid of the lung – a case report with pathological correlation and propagation of the cancer stem cell line BKZ1 with synaptophysin expression

Rationale: Neuroendocrine tumors (NETs) of the lung account for 5% of all cases of lung cancer, which itself is the leading cause of cancer-related death worldwide. In accordance to its rarity, only few cell lines of NETs exist, which even often lack key characteristics of the primary tumor, making it difficult to study underlying molecular mechanisms. Patient concerns: The patient reported in this case is a 71-year old woman, which never smoked but suffered under dry cough. diagnoses: Chest CT-scan showed a paracardiac nodule of the lingula with 2 × 1.8 cm in diameter. Interventions: The detected paracardiac nodule of the lingula was anatomically resected using video assisted thoracic surgery. Outcomes: Histopathological diagnostic of the removed tissue identified the tumor as a well-differentiated typical carcinoid (TC), which represents one of the four subgroups of pulmonary NETs. Next to the successful treatment of the patient, we were able to propagate cancer stem cells (CSCs) out of the resected tumor tissue. To the best of our knowledge, we firstly isolated CSCs of a typical carcinoid, which were positive for the prominent CSC markers CD44, CD133 and nestin, confirming their stem cell properties. Additionally, CSCs, further referred as BKZ1, expressed the neuroendocrine marker synaptophysin, verifying their neuroendocrine origin. However, nuclear synaptophysin protein was also present in other stem cell populations, suggesting a role as general st...
Source: Medicine - Category: Internal Medicine Tags: Research Article: Clinical Case Report Source Type: research

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Source: BMJ Comments - Category: General Medicine Source Type: forums
Publication date: January 2020Source: Biometric Technology Today, Volume 2020, Issue 1Author(s): US NIST (the National Institute of Standards and Technology) has released three new biometric databases – featuring fingerprints, facial photographs and iris scans – designed to help researchers reduce the error rates of biometric systems.
Source: Biometric Technology Today - Category: Information Technology Source Type: research
Publication date: January 2020Source: Biometric Technology Today, Volume 2020, Issue 1Author(s): Jason TooleyThe use of biometrics by police forces has rarely been out of the headlines over the past year. As with many emerging technologies, it has hit significant hurdles. Recently in an unprecedented move, the UK's Information Commissioner's Office (ICO) – the government body responsible for GDPR and data privacy enforcement – launched an independent investigation into the use of facial recognition at London's King's Cross train station, after it was revealed that the general public were having their faces scan...
Source: Biometric Technology Today - Category: Information Technology Source Type: research
DNA changes in a common type of breast cancer cell may be linked to hormone therapy resistance, according to a study published inNature Communications.Science Daily
Source: Society for Endocrinology - Category: Endocrinology Source Type: news
We have vacancies for the Editor-in-Chief positions on the Editorial Boards of Endocrine Connections and Endocrine-Related Cancer.Endocrine Connections is jointly owned by the Society for Endocrinology and the European Society of Endocrinology. It is an open access journal offering authors the highest possible visibility for their work and stimulating cross-discipline collaboration. Read the full job description.Endocrine-Related Cancer is the official flagship journal of the Society for Endocrinology and is endorsed by the European Society of Endocrinology, Endocrine Society of Australia...
Source: Society for Endocrinology - Category: Endocrinology Source Type: news
Conclusion The current level of awareness for clinical trials of cancer patients in our hospital was relatively low, even in patients who had atte nded clinical trials before. It’s necessary to improve patients’ awareness of clinical trial by promoting harmony relationship between patients and doctors, as well as by enhancing related propagation. Strengthening the adequacy and efficacy of informed consent in clinical trials also needs to b e achieved in the future. DOI: 10.3779/j.issn.1009-3419.2020.01.02
Source: Chinese Journal of Lung Cancer - Category: Cancer & Oncology Source Type: research
Conclusion T4 stage patients had worse survival in N2 group. To get a more precisely stratification, skip metastasis and number of involved lymph node stations should be considered in future N stage classification. 
 DOI: 10.3779/j.issn.1009-3419.2020.01.03
Source: Chinese Journal of Lung Cancer - Category: Cancer & Oncology Source Type: research
Conclusion: Lung carcinoid tumors are detected by 68Ga DOTA-NOC PET/CT with a high degree of sensitivity (91.7%) [1,2]. It also detects asymptomatic distant metastatic disease in a sizeable number of patients (11.7%) that leads to change in treatment strategy. Typical carcinoid tumors exhibit a higher degree of SSTR expression compared to atypical tumors and metastatic disease is more commonly seen with atypical carcinoid [3].
Source: Journal of Nuclear Medicine - Category: Nuclear Medicine Authors: Tags: Lung Cancer Posters Source Type: research
Rationale: Diffuse idiopathic pulmonary neuroendocrine cell hyperplasia (DIPNECH) is a rare idiopathic disease with only about 100 cases reported in the literature. Patient concerns: Here, we presented 4 cases of DIPNECH. Four patients included 2 females and 2 males, aged 54 to 64 years old; 3 had no smoking history and 1 had history of smoking for 30 years. Surgical resection was performed for every patient. Cases 1 and 3 did not receive postoperative chemotherapy or radiotherapy, and case 2 received 4 times of postoperative chemotherapy. Case 4 just finished the operation and after a period of time, he will receive ...
Source: Medicine - Category: Internal Medicine Tags: Research Article: Clinical Case Report Source Type: research
Conclusions: In most cases the patients did not have symptoms at diagnosis Bronchoscopy was the most frequent diagnosis method Lobectomy with lymphadenectomy was the intervention in the highest percentage of cases.
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: 11.1 Lung Cancer Source Type: research
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