Potential cytotoxic and anti-metastatic effects of berberine on gynaecological cancers with drug-associated resistance.

In conclusion, berberine has been found to efficiently inhibit viability, proliferation, and migration of cancer cells, mainly, via induction of apoptosis by both mitochondrial dependent and -independent pathways. Additionally, structural modification of berberine showed that berberine analogues can improve its antitumor effects against gynaecological cancers.
PMID: 31821990 [PubMed - as supplied by publisher]

Source: European Journal of Medicinal Chemistry - December 3, 2019 Category: Chemistry Authors: Mortazavi H, Nikfar B, Esmaeili SA, Rafieenia F, Saburi E, Chaichian S, Heidari Gorji MA, Momtazi-Borojeni AA Tags: Eur J Med Chem Source Type: research