Micro Glucagon During Exercise in Type 1 Diabetes
Conditions: Type 1 Diabetes; Hypoglycemia Interventions: Drug: Micro-glucagon; Drug: Mini-glucagon Sponsor: University Hospital Inselspital, Berne Not yet recruiting
Authors: Annibale B, Esposito G, Lahner E Abstract SUMMARYIntroduction: Atrophic gastritis (AG) is a complex syndrome which arise as consequence of H. pylori infection or in the context of gastric autoimmunity. It often deserves a benign course, but may lead to potentially life-threatening complications: cancer and anaemia. This review aims to address traditional and innovative knowledge on this often under-diagnosed disorder.Areas covered: This review covers clinical presentation, risk factors, diagnosis and management of AG and provides an updated resource for clinicians to get insight in this challenging disorde...
We describe evidence for substance use as a risk factor for new-onset diabetes, prevalence of use in people with diabetes, evidence linking substance use with diabetes-related health outcomes, and evidence on the management of these co-occurring conditions.
Conclusions: Based on an assessment of several glycemic outcomes, moderate-quality evidence shows that flash glucose monitoring improves diabetes management among adults with well-controlled type 1 diabetes and adults with type 2 diabetes requiring intensive insulin therapy. We estimate that publicly funding flash glucose monitoring in Ontario for people with type 1 diabetes and for people with type 2 diabetes requiring intensive insulin therapy who are eligible for coverage under the Ontario Drug Benefit program would result in additional costs of between $14.6 million and $38.6 million annually over the next 5 years. Adu...
ConclusionsMetformin can limit the development of atherosclerosis secondary to diabetes in young diabetic mice. A possible mechanism is the removal of methylglyoxal, thereby reducing the formation of advanced glycation endproducts, rather than by lowering the blood glucose level.FundingThis work was supported by the National Natural Science Foundation of China (81901106) and Jinan clinical medical science and technology innovation plan (201907002).
Diabetic peripheral neuropathy (DPN) is a common chronic complication of diabetes mellitus. It leads to distressing and expensive clinical sequelae such as foot ulceration, leg amputation, and neuropathic pain (painful-DPN). Unfortunately, DPN is often diagnosed late when irreversible nerve injury has occurred and its first presentation may be with a diabetic foot ulcer. Several novel diagnostic techniques are available which may supplement clinical assessment and aid the early detection of DPN. Moreover, treatments for DPN and painful-DPN are limited. Only tight glucose control in type 1 diabetes has robust evidence in re...
Renza Scibilia, manager of type 1 diabetes and consumer voice at Diabetes Australia, says diabetes is a data-driven health condition and those with the disease should be provided choices of treatment plans and supported in their choices.
Conclusion: Administration of CoQ10 for 3 months in T1DM pediatric patients was well tolerated but had no favorable effect on ED or metabolic parameters. PMID: 31942840 [PubMed - as supplied by publisher]
Condition: Type 1 Diabetes Mellitus With Hypoglycemia Intervention: Other: SUPPORT online platform for people with type 1 diabetes Sponsors: McGill University; Institut de Recherches Cliniques de Montreal; Juvenile Diabetes Research Foundation; Canadian Institutes of Health Research (CIHR) Not yet recruiting
Condition: Type1 Diabetes Interventions: Combination Product: HCL and placebo; Combination Product: HCL and verapamil; Combination Product: non-HCL and verapamil; Combination Product: non-HCL and placebo Sponsors: Jaeb Center for Health Research; University of Minnesota; Medtronic; Tandem Diabetes Care, Inc.; DexCom, Inc. Not yet recruiting
CONCLUSION: GDF11 can provide protection against MIR injury in diabetic rats, and is implicated in antioxidant stress and autophagy up-regulation. PMID: 31939595 [PubMed - in process]