Evaluation of the clinical impact of the revised ISSHP and ACOG definitions on preeclampsia

Publication date: Available online 11 December 2019Source: Pregnancy HypertensionAuthor(s): Anisha R. Bouter, Johannes J. DuvekotAbstractBackgroundIn 2018/2013 both ISSHP and ACOG revised their original statements and postulated new criteria for preeclampsia with and without severe features. Most importantly, preeclampsia can now also be established in the absence of proteinuria when other specific symptoms are present.ObjectiveWhat is the clinical impact of the use of three different new definitions for the diagnosis of preeclampsia?Study designRetrospective cohort study of all pregnant women who gave birth in the Erasmus MC between 01 and 01-2014 and 01-01-2016. Hypertensive disorders of pregnancy (HDP) were defined when blood pressure was elevated at least during two occasions. All HDP cases were classified according to the ISSHP 2001, ISSHP 2018 and ACOG 2013 definitions.ResultsIn our cohort (N = 4395) 878 patients had HDP (20,0%). The ISSHP 2018/ACOG 2013 definition cause a significant increase in patients with (superimposed) preeclampsia versus the ISSHP 2001 definition, from 272 patients (6,2%) to respectively 360 (8,2%)/290 (6,6%) (p 
Source: Pregnancy Hypertension: An International Journal of Womens Cardiovascular Health - Category: OBGYN Source Type: research

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Am J Perinatol DOI: 10.1055/s-0039-1701023The centuries-old approach to the prevention of eclampsia and its associated maternal morbidity and mortality is based on the recognition of the presence of premonitory signs and symptoms such as hypertension and proteinuria. The spectrum of preceding signs and symptoms came to be known as preeclampsia, which is debatably considered to be an early stage on a clinical continuum possibly leading to eclampsia. The premonitory signs and symptoms were then construed as diagnostic criteria for the poorly understood syndrome of preeclampsia, and this led to a perpetual debate that remains...
Source: American Journal of Perinatology - Category: Perinatology & Neonatology Authors: Tags: Commentary Source Type: research
Preeclampsia is a common obstetric syndrome affecting women in their first pregnancy and characterized by hypertension and proteinuria, which appears after 20  weeks of gestation. It is characterized by high bl...
Source: Stem Cell Research and Therapy - Category: Stem Cells Authors: Tags: Research Source Type: research
Publication date: Available online 10 January 2020Source: Pregnancy HypertensionAuthor(s): Mamoru Morikawa, Michinori Mayama, Yoshihiro Saito, Kinuko Nakagawa, Takeshi Umazume, Kentaro Chiba, Satoshi Kawaguchi, Kazutoshi Cho, Hidemichi WatariAbstractObjectivesThe present study aimed to determine the relationship between the severity of proteinuria and maternal/neonatal outcomes among women with preeclampsia.Study designProteinuria severity was measured at preeclampsia diagnosis and at delivery in 94 women with preeclampsia (among 2904 women with singleton pregnancies, who delivered after 22 gestational weeks). Preeclampsia...
Source: Pregnancy Hypertension: An International Journal of Womens Cardiovascular Health - Category: OBGYN Source Type: research
Preeclampsia and HELLP syndrome are pregnancy related disorders that are associated with sudden onset or increases in blood pressure, proteinuria, inflammation and with neurological changes. Studies have reported that circulating factors in the blood can contribute to blood brain barrier (BBB) damage in some women with these conditions. Using two animal models we tested the hypothesis that T cell activation during pregnancy is associated with increased BBB damage.
Source: American Journal of Obstetrics and Gynecology - Category: OBGYN Authors: Tags: Poster Session I Source Type: research
In the past three decades, the incidence of preeclampsia, characterized by hypertension, proteinuria and end organ damage, has significantly increased in the U.S., in association with an increase in maternal weight. There is a gap in our understanding regarding how obesity influences preeclampsia. Ankiryn-repeat-and-SOCS-box-containing-protein 4 (ASB4) contributes to the differentiation of trophoblast stem cells into the giant trophoblast cells necessary for embryo implantation in mice. ASB4-null females develop preeclampsia-like phenotypes during pregnancy.
Source: American Journal of Obstetrics and Gynecology - Category: OBGYN Authors: Tags: Poster Session V Source Type: research
Authors: Sun XM, Yang M, Jiang CX Abstract OBJECTIVE: The aim of this study was to analyze the association of ATPase plasma membrane Ca2+ transporting 1 (ATP2B1) gene polymorphism with the incidence of eclampsia, and to investigate the possible underlying mechanism. PATIENTS AND METHODS: ATP2B1 genotype and allele distributions in umbilical venous blood cells were analyzed in 50 control subjects and 117 eclampsia patients via Reverse Transcription-Polymerase Chain Reaction (RT-PCR) and TaqMan genotyping technique. Meanwhile, the differences in the single nucleotide polymorphisms at rs2681472 and rs17249754 in t...
Source: European Review for Medical and Pharmacological Sciences - Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research
Publication date: Available online 17 December 2019Source: Pregnancy HypertensionAuthor(s): Fouad Amraoui, Hajar Hassani Lahsinoui, Leon J.A. Spijkers, Liffert Vogt, Stephan L.M. Peters, Dayanjan S. Wijesinghe, Urszula O. Warncke, Charles E. Chalfant, Carrie Ris-Stalpers, Bert-Jan H. van den Born, Gijs B. AfinkAbstractObjectivesCeramide is a sphingolipid with anti-angiogenic and pro-apoptotic properties that has shown to be increased in plasma of women with pre-eclampsia. We aimed to compare plasma and placental sphingolipid content among normotensive pregnant women and pre-eclamptic women with and without HELLP syndrome a...
Source: Pregnancy Hypertension: An International Journal of Womens Cardiovascular Health - Category: OBGYN Source Type: research
This study aimed to analyse maternal and foetal condition and pregnancy outcomes of PE patients with different IOS, and to explore the disease progression and characteristics of maternal and foetal outcomes for different IOS, so as to provide the basis for future maternal and foetal monitoring of PE patients.Impact statementWhat is already known on this subject? In 2013, the American College of Obstetricians and Gynecologists revised their definition of PE, sparking a heated debate. Subsequently in 2015, China updated its guidelines to define PE as hypertensive pregnancy accompanied by involvement of any other organ or org...
Source: Journal of Obstetrics and Gynaecology - Category: OBGYN Tags: J Obstet Gynaecol Source Type: research
AI Abstract Preeclampsia is a serious vascular complication of the human pregnancy, whose etiology is still poorly understood. In preeclampsia, exacerbated apoptosis and fragmentation of the placental tissue occurs due to developmental qualities of the placental trophoblast cells and/or mechanical and oxidative distress to the syncytiotrophoblast, which lines the placental villi. Dysregulation of the complement system is recognized as one of the mechanisms of the disease pathology. Complement has the ability to promote inflammation and facilitate phagocytosis of placenta-derived particles and apoptotic cells by m...
Source: Seminars in Immunology - Category: Allergy & Immunology Authors: Tags: Semin Immunol Source Type: research
Abstract Preeclampsia (PE) is termed as an obstetric issue that is characterized by hypertension (≧140/90 mm Hg), together with proteinuria following 20 weeks of pregnancy. Until today, PE still constitutes a severe threat to the lives of both the mothers and fetuses. In the past, long noncoding RNAs (lncRNAs) were considered as the transcriptional noise. However, some investigations have indicated that lncRNAs could be used as innovative indicators in PE. The current review aims to discuss the relationship between lncRNAs and PE in recent years. According to the retrieved data, we concluded that lncRNAs ...
Source: Biomed Res - Category: Research Authors: Tags: Biomed Res Int Source Type: research
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