Non-enhanced Magnetic Resonance Imaging as a Surveillance Tool for Hepatocellular Carcinoma: Comparison with Ultrasound

Recently revised international guidelines for hepatocellular carcinoma (HCC) suggest that selected patients with inadequate surveillance ultrasonography to be assessed by alternative imaging modalities such as computed tomography or magnetic resonance imaging (MRI). MRI with contrast material has drawbacks associated with the use of gadolinium contrast agent. Non-enhanced MRI consisted of diffusion-weighted imaging and T2-weighted imaging showed significantly better performance than ultrasonography as a surveillance tool for HCC in a high-risk prospective cohort. The estimated scan time of non-enhanced MRI was less than 6 minutes. Given the high performance, short scan time, and the lack of contrast agent-associated risks, non-enhanced MRI has potential to be an option for surveillance of HCC in high-risk patients.
Source: Journal of Hepatology - Category: Gastroenterology Authors: Source Type: research

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Authors: Zhang Y, Ying X, Zhao Q, Ma J, Zhang D, He C, Han S Abstract Background: Hepatocellular carcinoma (HCC) is a malignant tumor associated with a poor prognosis. Serum biomarkers of HCC have the potential to improve the diagnosis, provide a means to monitor the tumors, and predict their malignancy. Proteins that are expressed differentially between HCC patients and normal controls have the potential to be biomarkers. Method: Serum samples from 10 confirmed HCC patients and 10 controls were collected. The differentially expressed proteins in the serum were identified using an isobaric tags for relative and...
Source: Disease Markers - Category: Laboratory Medicine Tags: Dis Markers Source Type: research
Authors: Yasuda D, Ohe T, Takahashi K, Imamura R, Kojima H, Okabe T, Ichimura Y, Komatsu M, Yamamoto M, Nagano T, Mashino T Abstract Resistance to anticancer agents has been an obstacle to developing therapeutics and reducing medical costs. Whereas sorafenib is used for the treatment of human hepatocellular carcinoma (HCC), resistance limits its efficacy. p62, a multifunctional protein, is overexpressed in several HCC cell lines, such as Huh-1 cells. Phosphorylated p62 (p-p62) inhibits the protein-protein interaction (PPI) between Keap1 and Nrf2, resulting in the Nrf2 overactivation that causes drug resistance. We ...
Source: Free Radical Research - Category: Research Tags: Free Radic Res Source Type: research
Publication date: Available online 21 February 2020Source: European Journal of RadiologyAuthor(s): Mathis Eichler, Matthias May, Marco Wiesmueller, Marc Saake, Rafael Heiss, Michael Uder, Wolfgang WuestAbstractPurposeAim of this study was to evaluate image quality of single source dual energy CT (SSDE-CT) using split filter technique in oncologic abdominal CT.Method51 consecutive patients with newly diagnosed breast carcinoma were prospectively enrolled in this study and underwent a staging examination of the abdomen using SSDE-CT (120 kV, split filter technique, 400 ref. mAs). Inline default images (DI) and post-pr...
Source: European Journal of Radiology - Category: Radiology Source Type: research
ConclusionsLI-RADS shows high diagnostic accuracy in diagnosing of HCC with a pooled sensitivity of 0.86 and specificity of 0.85, and specificity is higher for LR-5 or LR ≥ 5. However, further prospective studies of LI-RADS are needed to elucidate its value for diagnosing of small HCCs (≤20 mm).
Source: European Journal of Radiology - Category: Radiology Source Type: research
CONCLUSION: The present data indicate that VOPP1 may play an important role in the progression of HCC by targeting the MAPK and mTOR signalling pathways, and that VOPP1 may potentially be a candidate as a novel molecular target for HCC therapy. PMID: 32083568 [PubMed - as supplied by publisher]
Source: Cancer Biomarkers - Category: Cancer & Oncology Tags: Cancer Biomark Source Type: research
Publication date: Available online 21 February 2020Source: Clinica Chimica ActaAuthor(s): Anbo Gao, Jinyong Jiang, Feng Xie, Linxi ChenAbstractThe present review is a summary of the recent literature concerning Bnip3 expression, function, and regulation, along with its implications in mitochondrial dysfunction, disorders of mitophagy homeostasis, and development of diseases of secondary mitochondrial dysfunction. As a member of the Bcl-2 family of cell death-regulating factors, Bnip3 mediates mPTP opening, mitochondrial potential, oxidative stress, calcium overload, mitochondrial respiratory collapse, and ATP shortage of m...
Source: Clinica Chimica Acta - Category: Laboratory Medicine Source Type: research
Publication date: Available online 21 February 2020Source: Urology Case ReportsAuthor(s): Irzi Mohamed, EL Houmaidi Amine, Mhanna Tarik, Ouraghi Abdelghani, Alaoui Mhammedi wassim, Barki AliAbstractUsual location of metastasis are in renal cell carcinoma (RCC) the lung, liver, bone, adrenal and brain. Here we report on an unusual case of a 76-year-old male with a solitary sternal metastasis as an initial presentation of clear-cell RCC.The management of metastatic kidney cancer has been disrupted over the last decade by the emergence of new treatments and the progress of surgery and ablative techniques.the Carmena study sug...
Source: Urology Case Reports - Category: Urology & Nephrology Source Type: research
Authors: Li G, Shen Y, Wang F, Hong S, Cai M Abstract BACKGROUND We investigated the relationship between the 18F-FDG PET/CT metabolic parameter SUVmax in primary hepatocellular carcinoma (HCC) and expression of von Hippel-Lindau (VHL), as well as its effect on HCC survival prognosis. MATERIAL AND METHODS We retrospectively analyzed data for 62 HCC patients who received 18F-FDG PET/CT before surgery at the First Affiliated Hospital of Bengbu Medical College from June 2013 to June 2018 (42 males, 20 females; median age 62 years). No treatment was performed prior to the examination. The relationship between preoperat...
Source: Medical Science Monitor - Category: Research Tags: Med Sci Monit Source Type: research
ConclusionsCirrhotic patients have higher odds of developing pulmonary complications, ascites, and anastomotic leak during the first postoperative month. Although, 30-day mortality was higher among cirrhotic patients after esophagectomy, liver disease does not seem to influence long-term prognosis.
Source: The American Journal of Surgery - Category: Surgery Source Type: research
Objective: The aim of the study is to assess the efficacy and safety of associating liver partition and portal vein ligation for staged hepatectomy (ALPPS) in patients with hepatitis B virus-related hepatocellular carcinoma (HCC). Background: ALPSS allows curative resection of conventionally-unresectable liver tumors. However, its role in HCC is largely unknown. Methods: Consecutive HCC patients who underwent ALPPS at our center between April 2013 and September 2017 were retrospectively studied. The oncological results were compared with patients receiving transcatheter arterial chemoembolization (TACE), and patien...
Source: Annals of Surgery - Category: Surgery Tags: ORIGINAL ARTICLES Source Type: research
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