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Source: Annals of Allergy, Asthma and Immunology - Category: Allergy & Immunology Source Type: research

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In this study we examined the effect of Compound A, N-(2-Aminoethyl)-5-chloro-1H-indol-2-carboxamide a H4 receptor antagonist in allergic asthma mice model. Objective: To investigate the anti-asthmatic effect of compound A in in vivo, airway inflammation in ovalbumin (OVA) induced allergic asthma mouse model was used.Methodology: Allergic asthma was induced in Balb/c mice using ovalbumin. BAL fluid was examined for the level of IgE, IL-4, IL-5, IL-13 and IL-17 using ELISA. Furthermore, infiltration of leucocytes by histopathology and effect of compound A on signalling molecules were examined in lung tissue.Results: In mice...
Source: Immunological Investigations - Category: Allergy & Immunology Tags: Immunol Invest Source Type: research
Source: Journal of Asthma and Allergy - Category: Allergy & Immunology Tags: Journal of Asthma and Allergy Source Type: research
Are asthma patients who use inhaled corticosteroids at an increased risk for pneumonia and hospitalization?BMC Pulmonary Medicine
Source: Medscape Allergy Headlines - Category: Allergy & Immunology Tags: Pulmonary Medicine Journal Article Source Type: news
AbstractPurpose of ReviewProgestogen hypersensitivity (PH) is a condition which typically occurs in women in childbearing years with a spectrum of symptoms ranging from urticaria with or without angioedema, dermatitis to systemic anaphylaxis. Herein, a clinical case of PH is presented followed by a discussion on the evaluation, diagnosis, and management of PH.Recent FindingsProgestogen hypersensitivity (a.k.a. “autoimmune progesterone dermatitis”) symptoms are associated with exogenous progestin exposure (e.g., contraceptive medicines, in vitro fertilization therapy) or endogenous progesterone from progesterone...
Source: Current Allergy and Asthma Reports - Category: Allergy & Immunology Source Type: research
Allergic rhinitis is a prevalent disease, which can be classed as seasonal (SAR), or perennial. In addition to nasal symptoms, up to 75% of sufferers experience itching, redness and tearing of the eyes. Intranasal corticosteroids are effective in controlling the allergic nasal symptoms, and there is increasing evidence suggesting they can also relieve some of the allergic ocular symptoms.
Source: Annals of Allergy, Asthma and Immunology - Category: Allergy & Immunology Authors: Source Type: research
Food Protein-Induced Enterocolitis Syndrome (FPIES) is a non-IgE-mediated food allergy that presents with severe vomiting and lethargy, with or without diarrhea, within 1-4 hours of ingestion of a trigger food antigen1. In about 15% of cases, the reaction may be severe enough to cause hypotension and shock. Prevalence of FPIES is likely underestimated, with a reported incidence of 0.34% to 0.7% amongst infants2,3. Although FPIES in adults has been reported, it is typically a disease of young children.
Source: Annals of Allergy, Asthma and Immunology - Category: Allergy & Immunology Authors: Tags: Letters Source Type: research
As an asthma specialist, one is often asked to discuss the asthma guidelines. The challenge that one faces is what guidelines do you use as a resource for discussion or presentation? It often comes down to: What is the question? What message does one want to deliver? And where is the most current information? Who is the target audience? This commentary will help answer those questions as it guides the reader through the new draft update of the NHLBI/NAEPP guidelines and then outlines differences between two widely used strategies for the management of asthma: the Global Initiative for Asthma (GINA) and the National Heart, ...
Source: Journal of Allergy and Clinical Immunology - Category: Allergy & Immunology Authors: Source Type: research
Serum IL-6 was associated with asthma exacerbation risk but not with symptoms or lung function in urban children; further studies to evaluate the role of IL-6 in the life course of asthma are needed.
Source: Journal of Allergy and Clinical Immunology - Category: Allergy & Immunology Authors: Source Type: research
Indoor environmental control practices are effective in reducing asthma symptoms among children. How do these practices differ by race/ethnicity in households with children with asthma in the US?Preventing Chronic Disease
Source: Medscape Allergy Headlines - Category: Allergy & Immunology Tags: Public Health & Prevention Journal Article Source Type: news
AbstractEarly life environmental risk factors are associated with chronic respiratory morbidity in child- and adulthood. A possible mechanism for this sustained effect is their influence on early life lung functional growth and development, a susceptible phase of rapid lung growth with increased plasticity. We summarize evidence of hereditary and environmental ante-, peri-, and early postnatal factors on lung functional development, such as air pollution, tobacco exposure, nutrition, intrauterine growth retardation, prematurity, early life infections, microbiome, and allergies and their effect on lung functional trajectori...
Source: Seminars in Immunopathology - Category: Pathology Source Type: research
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