Rapid desensitization of humanized mice with anti-human Fc εRIα monoclonal antibodies

Although inoculating humanized mice with a large dose of anti-human Fc εRIα mAb induces anaphylaxis, administering the same mAb through a rapid desensitization approach safely removes nearly all IgE from mast cells and blocks IgE-mediated anaphylaxis.

Source: Journal of Allergy and Clinical Immunology - December 9, 2019 Category: Allergy & Immunology Authors: Marat V. Khodoun, Suzanne C. Morris, Elizabeth Angerman, Crystal Potter, Richard Schuman, Mark Wunderlich, Joseph J. Maciag, Kathryn C. Sullivan Locker, James C. Mulloy, Andrew B. Herr, Fred D. Finkelman Source Type: research