Crucial role of NLRP3 inflammasome in a murine model of Kawasaki disease

Kawasaki disease (KD) is a systemic febrile syndrome during childhood that is characterized by coronary arteritis. The etiopathogenesis of KD remains to be elucidated. NLRP3 inflammasome is a large multiprotein complex that plays a key role in IL-1 β-driven sterile inflammatory diseases. In the present study, we investigated the role of NLRP3 inflammasome in a murine model of KD induced by Candida albicans water-soluble fraction (CAWS) and found that NLRP3 inflammasome is required for the development of CAWS-induced vasculitis.

Source: Journal of Molecular and Cellular Cardiology - December 9, 2019 Category: Cytology Authors: Fumiya Anzai, Sachiko Watanabe, Hiroaki Kimura, Ryo Kamata, Tadayoshi Karasawa, Takanori Komada, Jun Nakamura, Noriko Nagi-miura, Naohito Ohno, Yasuchika Takeishi, Masafumi Takahashi Source Type: research