Defining decreased protein succinylation of failing human cardiac myofibrils in ischemic cardiomyopathy

Succinylation is a post-translational modification of protein lysine residues with succinyl groups derived from succinyl CoA. Succinylation is considered a significant post-translational modification with the potential to impact protein function which is highly conserved across numerous species. The role of succinylation in the heart, especially in heart failure and myofibril mechanics, remains largely unexplored. Mechanical parameters were measured in myofibrils isolated from failing hearts of ischemic cardiomyopathy patients and non-failing donor controls.

Source: Journal of Molecular and Cellular Cardiology - December 9, 2019 Category: Cytology Authors: Hadi R. Ali, Cole R. Michel, Ying H. Lin, Timothy A. McKinsey, Mark Y. Jeong, Amrut V. Ambardekar, Joseph C. Cleveland, Richard Reisdorph, Nichole Reisdorph, Kathleen C. Woulfe, Kristofer S. Fritz Source Type: research