Simvastatin attenuates lung functional and vascular effects of hyperoxia in preterm rabbits.

CONCLUSION: Repurposing of simvastatin could be an advantageous therapeutic strategy for bronchopulmonary dysplasia and other developmental lung diseases with pulmonary vascular disease. The increased mortality in the treated normoxia group however limits the translational value at this dose and administration route.
PMID: 31816623 [PubMed - as supplied by publisher]

Source: Pediatric Research - December 8, 2019 Category: Pediatrics Authors: Salaets T, Tack B, Jimenez J, Gie A, Lesage F, de Winter D, Berghen N, Allegaert K, Deprest J, Toelen J Tags: Pediatr Res Source Type: research