Cell transformation by the Adenovirus oncogenes E1 and E4

AbstractExtensive studies on viral ‐mediated oncogenic transformation by human adenoviruses have revealed much of our current understanding on the molecular mechanisms that are involved in the process. To date, these studies have shown that cell transformation is a multistep process regulated by the cooperation of several adenovira l gene products encoded in the early regions 1 (E1) and 4 (E4). E1A immortalizes primary rodent cells, whereas coexpression of E1B induces full manifestation of the transformed phenotype. Beside E1 proteins, also some E4 proteins have partial transforming activities through regulating many cellular pathways. Here, we summarize recent data of how adenoviral oncoproteins may contribute to viral transformation and discuss the challenge of pinpointing the underlying mechanisms.

Source: FEBS Letters - December 9, 2019 Category: Biochemistry Authors: Wing Hang Ip, Thomas Dobner Tags: IN A NUTSHELL Source Type: research