Arousal regulates frequency tuning in primary auditory cortex [Neuroscience]

Changes in arousal influence cortical sensory representations, but the synaptic mechanisms underlying arousal-dependent modulation of cortical processing are unclear. Here, we use 2-photon Ca2+ imaging in the auditory cortex of awake mice to show that heightened arousal, as indexed by pupil diameter, broadens frequency-tuned activity of layer 2/3 (L2/3) pyramidal...

Source: Proceedings of the National Academy of Sciences - December 9, 2019 Category: Science Authors: Pei-Ann Lin, Samuel K. Asinof, Nicholas J. Edwards, Jeffry S. Isaacson Tags: Biological Sciences Source Type: research