Human iPSC-derived microglia assume a primary microglia-like state after transplantation into the neonatal mouse brain [Neuroscience]
Microglia are essential for maintenance of normal brain function, with dysregulation contributing to numerous neurological diseases. Protocols have been developed to derive microglia-like cells from human induced pluripotent stem cells (hiPSCs). However, primary microglia display major differences in morphology and gene expression when grown in culture, including down-regulation of signature...
Source: Proceedings of the National Academy of Sciences - Category: Science Authors: Devon S. Svoboda, M. Inmaculada Barrasa, Jian Shu, Rosalie Rietjens, Shupei Zhang, Maya Mitalipova, Peter Berube, Dongdong Fu, Leonard D. Shultz, George W. Bell, Rudolf Jaenisch Tags: Biological Sciences Source Type: research
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