Transcriptomic, epigenetic, and functional analyses implicate neutrophil diversity in the pathogenesis of systemic lupus erythematosus [Immunology and Inflammation]

Neutrophil dysregulation is implicated in the pathogenesis of systemic lupus erythematosus (SLE). SLE is characterized by elevated levels of a pathogenic neutrophil subset known as low-density granulocytes (LDGs). The origin and phenotypic, functional, and pathogenic heterogeneity of LDGs remain to be systematically determined. Transcriptomics and epigenetic assessment of lupus LDGs,...

Source: Proceedings of the National Academy of Sciences - December 9, 2019 Category: Science Authors: Pragnesh Mistry, Shuichiro Nakabo, Liam O’Neil, Rishi R. Goel, Kan Jiang, Carmelo Carmona–Rivera, Sarthak Gupta, Diana W. Chan, Philip M. Carlucci, Xinghao Wang, Faiza Naz, Zerai Manna, Amit Dey, Nehal N. Mehta, Sarfaraz Hasni, Stefania Dell& Tags: Biological Sciences Source Type: research