Galnt11 regulates kidney function by glycosylating the endocytosis receptor megalin to modulate ligand binding [Genetics]

Chronic kidney disease (CKD) affects more than 20 million Americans and ∼10% of the population worldwide. Genome-wide association studies (GWAS) of kidney functional decline have identified genes associated with CKD, but the precise mechanisms by which they influence kidney function remained largely unexplored. Here, we examine the role of 1...

Source: Proceedings of the National Academy of Sciences - December 9, 2019 Category: Science Authors: E. Tian, Shengjun Wang, Liping Zhang, Ying Zhang, May C. Malicdan, Yang Mao, Christina Christoffersen, Lawrence A. Tabak, Katrine T. Schjoldager, Kelly G. Ten Hagen Tags: Biological Sciences Source Type: research