A structural basis for antibody-mediated neutralization of Nipah virus reveals a site of vulnerability at the fusion glycoprotein apex [Biochemistry]

Nipah virus (NiV) is a highly pathogenic paramyxovirus that causes frequent outbreaks of severe neurologic and respiratory disease in humans with high case fatality rates. The 2 glycoproteins displayed on the surface of the virus, NiV-G and NiV-F, mediate host-cell attachment and membrane fusion, respectively, and are targets of the...

Source: Proceedings of the National Academy of Sciences - December 9, 2019 Category: Science Authors: Victoria A. Avanzato, Kasopefoluwa Y. Oguntuyo, Marina Escalera-Zamudio, Bernardo Gutierrez, Michael Golden, Sergei L. Kosakovsky Pond, Rhys Pryce, Thomas S. Walter, Jeffrey Seow, Katie J. Doores, Oliver G. Pybus, Vincent J. Munster, Benhur Lee, Thomas A. Tags: Biological Sciences Source Type: research