Single-molecule imaging of HIV-1 envelope glycoprotein dynamics and Gag lattice association exposes determinants responsible for virus incorporation [Microbiology]

The HIV-1 envelope glycoprotein (Env) is sparsely incorporated onto assembling virus particles on the host cell plasma membrane in order for the virus to balance infectivity and evade the immune response. Env becomes trapped in a nascent particle on encounter with the polymeric viral protein Gag, which forms a dense...

Source: Proceedings of the National Academy of Sciences - December 9, 2019 Category: Science Authors: Nairi Pezeshkian, Nicholas S. Groves, Schuyler B. van Engelenburg Tags: PNAS Plus Source Type: research