A universal transportin protein drives stochastic choice of olfactory neurons via specific nuclear import of a sox-2-activating factor [Developmental Biology]

Stochastic neuronal cell fate choice involving notch-independent mechanisms is a poorly understood biological process. The Caenorhabditis elegans AWC olfactory neuron pair asymmetrically differentiates into the default AWCOFF and induced AWCON subtypes in a stochastic manner. Stochastic choice of the AWCON subtype is established using gap junctions and SLO BK potassium...

http://www.pnas.org/content/116/50/25137.short?rss=1

Source: Proceedings of the National Academy of Sciences - December 9, 2019 Category: Science Authors: Amel Alqadah, Yi-Wen Hsieh, Rui Xiong, Bluma J. Lesch, Chieh Chang, Chiou-Fen Chuang Tags: PNAS Plus Source Type: research