Resolving titin’s lifecycle and the spatial organization of protein turnover in mouse cardiomyocytes [Cell Biology]
Cardiac protein homeostasis, sarcomere assembly, and integration of titin as the sarcomeric backbone are tightly regulated to facilitate adaptation and repair. Very little is known on how the>3-MDa titin protein is synthesized, moved, inserted into sarcomeres, detached, and degraded. Here, we generated a bifluorescently labeled knockin mouse to simultaneously...
Source: Proceedings of the National Academy of Sciences - Category: Science Authors: Franziska Rudolph, Judith Huttemeister, Katharina da Silva Lopes, Rene Juttner, Lily Yu, Nora Bergmann, Dhana Friedrich, Stephan Preibisch, Eva Wagner, Stephan E. Lehnart, Carol C. Gregorio, Michael Gotthardt Tags: PNAS Plus Source Type: research