CNS Penetration of Cyclophosphamide and Metabolites in Mice Bearing Group 3 Medulloblastoma and Non-Tumor Bearing Mice.

CONCLUSIONS: Future studies will explore potential mechanisms at the brain-tumor barrier to explain lower cyclophosphamide brain penetration in tumor-bearing mice. These results will be used to further investigate exposure-response relationships in medulloblastoma xenograft models.
PMID: 31815662 [PubMed - in process]

Source: J Pharm Pharm Sci - December 11, 2019 Category: Drugs & Pharmacology Authors: Stewart C, Campagne O, Davis A, Zhong B, Nair S, Haberman V, T Patel Y, Janke L, F Roussel M Tags: J Pharm Pharm Sci Source Type: research