Calciphylaxis: Approach to Diagnosis and Management

Publication date: November 2019Source: Advances in Chronic Kidney Disease, Volume 26, Issue 6Author(s): Harish Seethapathy, Lama NoureddineCalciphylaxis is a rare disorder of poor prognosis that can lead to intense, painful lesions involving the skin and subcutaneous tissue. Although mostly described in dialysis patients, it can affect patients with normal kidney function. The diagnosis of calciphylaxis is complicated by the absence of a gold standard marker of disease such as a clear histopathological finding. Late diagnosis and advanced lesions can significantly shorten life expectancy. Calciphylaxis wounds can have a major influence on the quality of life of patients, usually due to the immense unbearable pain these patients suffer from. The management of calciphylaxis mainly comprises aggressive wound care and symptomatic management. Therapeutic options are few and far between and are limited to off-label uses. Recent understanding of the pathogenesis of lesions has enabled development of novel therapeutic options, some of which are being studied in clinical trials (sodium thiosulfate, vitamin K). Vascular calcification and thrombosis underlie development of these lesions and research has been aimed at studying drugs that counteract such processes. Future research is required to establish clear causal pathways and improve on the treatment options currently available to patients.
Source: Advances in Chronic Kidney Disease - Category: Urology & Nephrology Source Type: research

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Source: Frontiers in Neurology - Category: Neurology Source Type: research
Internal jugular vein (IJV) thrombosis is a rare vascular event. It is most commonly due to prolonged central venous catheterization, infection, ovarian hyperstimulation syndrome, intravenous drug abuse, malignancy or primary. We have present here a case of a 82- year- old male with chronic kidney disease who presented with left neck swelling and pain who was found to have a thrombus in the left internal internal jugular vein. He was successfully treated with conservative treatment without any complications.
Source: Annals of Vascular Surgery - Category: Surgery Authors: Tags: Case Report Source Type: research
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Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research
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Source: Blood - Category: Hematology Authors: Tags: 651. Myeloma: Biology and Pathophysiology, excluding Therapy: Poster III Source Type: research
Publication date: November 2017 Source:Journal of the American College of Radiology, Volume 14, Issue 11, Supplement Author(s): Alexander Z. Copelan, Baljendra S. Kapoor, Ali F. AbuRahma, Thomas R. Cain, Drew M. Caplin, Khashayar Farsad, M-Grace Knuttinen, Margaret H. Lee, Joseph J. McBride, Jeet Minocha, Stephen P. Reis, Paul J. Rochon, Colette M. Shaw, Jonathan M. Lorenz Iliac artery occlusive disease can present as a sudden-onset acute thrombotic or thromboembolic event or as a chronic progressive atherosclerotic process that presents as claudication progressing to rest pain. Depending on the clinical presentation, the...
Source: Journal of the American College of Radiology - Category: Radiology Source Type: research
MedTech Strategist working together with The Medical Alley Association for the very first time brought their premier innovation summit to Minnesota, a place now considered by many to be the global epicenter of health innovation and care. Over the two...
Source: Medgadget - Category: Medical Devices Authors: Tags: Exclusive Source Type: blogs
In this study, we have shown that the lipid chaperones FABP4/FABP5 are critical intermediate factors in the deterioration of metabolic systems during aging. Consistent with their roles in chronic inflammation and insulin resistance in young prediabetic mice, we found that FABPs promote the deterioration of glucose homeostasis; metabolic tissue pathologies, particularly in white and brown adipose tissue and liver; and local and systemic inflammation associated with aging. A systematic approach, including lipidomics and pathway-focused transcript analysis, revealed that calorie restriction (CR) and Fabp4/5 deficiency result ...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
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Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
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Source: Innovations in Clinical Neuroscience - Category: Neuroscience Authors: Tags: Anxiety Disorders Behavioral and Cognitive Neurology Case Report Cognition Current Issue Dementia Medical Issues Neurologic Systems and Symptoms Psychiatry Schizophrenia delusions hippocampus neurobiology Transient global amnesia Source Type: research
This case was sent by one of our great FOAM colleagues, Salim Rezaie of REBEL EM!!"A 67 y/o female with PMH of Type 2 DM, HTN, Hyperlipidemia, and Hx of MI x 2, with chronic kidney disease awoke at 2am with left sided chest pain. She arrived at 2:45 AM and had this initial ECG below:"What do you think? Smith response: There is sinus rhythm.  There is No significant ST elevation in any lead.   There are large, symmetric T-waves in I, aVL, V2-V5 diagnostic of proximal LAD occlusion.  There are also down-up T-waves in III and aVF (these are very specific RECIPROCAL findings and clinch the di...
Source: Dr. Smith's ECG Blog - Category: Cardiology Authors: Source Type: blogs
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