Micro Glucagon During Exercise in Type 1 Diabetes

Conditions:   Type 1 Diabetes;   Hypoglycemia Interventions:   Drug: Micro-glucagon;   Drug: Mini-glucagon Sponsor:   University Hospital Inselspital, Berne Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials

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Driving blood glycaemia from hyperglycaemia to euglycaemia as fast as possible while avoiding hypoglycaemia is a major problem for decades for type-1 diabetes and is solved in this study. A control algorithm is designed that guaranties hypoglycaemia avoidance for the first time both from the theory of positive systems point of view and from the most pragmatic clinical practice. The solution consists of a state feedback control law that computes the required hyperglycaemia correction bolus in real-time to safely steer glycaemia to the target. A rigorous proof is given that shows that the control-law respects the positivity ...
Source: IET Systems Biology - Category: Biology Source Type: research
In this study, a multiple-model strategy is evaluated as an alternative closed-loop method for subcutaneous insulin delivery in type 1 diabetes. Non-linearities of the glucose–insulin regulatory system are considered by modelling the system around five different operating points. After conducting some identification experiments in the UVA/Padova metabolic simulator (accepted simulator by the US Food and Drug Administration (FDA)), five transfer functions are obtained for these operating points. Paying attention to some physiological facts, the control objectives such as the required settling time and permissible boun...
Source: IET Systems Biology - Category: Biology Source Type: research
In this study, a closed-loop control scheme is proposed for the glucose–insulin regulatory system in type-1 diabetic mellitus (T1DM) patients. Some innovative hybrid glucose–insulin regulators have combined artificial intelligence such as fuzzy logic and genetic algorithm with well known Palumbo model to regulate the blood glucose (BG) level in T1DM patients. However, most of these approaches have focused on the glucose reference tracking, and the qualitative of this tracking such as chattering reduction of insulin injection has not been well-studied. Higher-order sliding mode (HoSM) controllers have been emplo...
Source: IET Systems Biology - Category: Biology Source Type: research
Over 30 million people in the United States live with diabetes, and approximately 7.7 million people have diabetic retinopathy, making it the most common cause of vision loss in working-aged adults. The prevalence of diabetic retinopathy has increased significantly over the past 20 years, due to the rise in the number of people diagnosed with diabetes. How does diabetes affect the retina? The retina is the light-sensing component located in the back of the eye. It is composed of blood vessels, nerve cells (neurons), and specialized cells called photoreceptors that are involved in directly sensing light. The ability of the ...
Source: Harvard Health Blog - Category: Consumer Health News Authors: Tags: Diabetes Eye Health Source Type: blogs
THURSDAY, Jan. 16, 2020 -- In women with prepregnancy type 1 and 2 diabetes mellitus (PDM), induction of labor (IOL) is not associated with increased cesarean section rates compared with expectant management beyond 39 weeks, but it is associated...
Source: Drugs.com - Pharma News - Category: Pharmaceuticals Source Type: news
To the Editor,
Source: Diabetes Research and Clinical Practice - Category: Endocrinology Authors: Source Type: research
The aim of this study was to investigate the efficacy and safety of continuous subcutaneous insulin infusion (CSII) regarding glycaemic control and quality of life in patients with type 1 diabetes mellitus (T1DM), who were previously treated with a multiple daily injections (MDI).
Source: Diabetes Research and Clinical Practice - Category: Endocrinology Authors: Source Type: research
Efforts to cut toxicity of treatment credited for drop in heart disease risk in survivors of childhood cancer Related items fromOnMedica Only half of new cancer drugs extend or improve life Women treated for cancer have higher CHF risk in pregnancy Metformin doesn ’t help HbA1c in teens with type 1 diabetes US doctor says FDA should have withdrawn rosuvastatin Codeine not to be used for coughs and colds in children under 12
Source: OnMedica Latest News - Category: UK Health Source Type: news
Scientists at the University of Warwick used artificial intelligence to detect low blood sugar by tracking a patient's heart rate using an electrocardiogram.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news
The Alliance for Advancing Bioelectronic Medicine (AABM) aims to play a unique convening role for the industry, mobilizing patients, physicians, and other stakeholders to advocate for the field, as well as to engage new audiences such as policy makers, investors, media, and the general public. MD+DI recently spoke with Barry Keenan, vice president of engineering at BioSig Technologies, a company that is one of the initial supporters of the AABM, about the growth and potential of the bioelectronic medicine market. When asked why the bioelectronic market is important in healthcare, Keenan said that bioelectronic medicine has...
Source: MDDI - Category: Medical Devices Tags: Electronics Source Type: news
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