V114 and Acute Otitis Media (V114-032/PNEU-ERA)
Condition: Acute Otitis Media (AOM) Interventions: Biological: V114; Other: Pediatric vaccines Sponsor: Merck Sharp & Dohme Corp. Not yet recruiting
Abstract Pneumococcal disease is a substantial contributor to illness and death in young children globally. The introduction of 7-valent pneumococcal conjugate vaccine (PCV7) in 2000 had a significant impact in preventing pneumococcal disease in both vaccinated children and unvaccinated individuals (through herd effect). A higher valent PCV13 replaced PCV7 in late 2009. This analysis was undertaken to assess how many cases and deaths have been averted over the last decade since PCV13 introduction. A model estimated the number of infants vaccinated annually with PCV13, as well as the number of cases and deaths of i...
Conclusions: Antimicrobial use and TTP procedures reduced in unvaccinated children after PCV10 introduction in infants. These indirect effects contribute to the savings in health care resource use for otitis and may also help in combating antimicrobial resistance.
CONCLUSION: Results suggest a lower LRTI and OM risk associated with PCV use in this high-risk population but respiratory disease risk remains high compared with the general population in Quebec. PMID: 32730119 [PubMed - as supplied by publisher]
Pneumococcal conjugate vaccines (PCVs) have led to substantial declines in vaccine-type pneumococcal disease through direct protection of vaccinated persons as well as indirect protection of unvaccinated persons by reducing nasopharyngeal carriage and transmission.1,2 Despite this success, an estimated 4 million pneumococcal disease cases and 22,000 related deaths occur annually in the United States, with otitis media alone causing 1 •5 million cases in 2013.3 These infections are often treated with antibiotics, leading to growing concerns regarding Streptococcus pneumoniae antimicrobial resistance (AMR).
ConclusionsPCV7/PCV13 sequential introduction resulted in rapid and substantial ANSP-OM reduction, in parallel with the near disappearance of PCV13-serotype OM and no increase in replacement disease.
Authors: Horáčková K, Ševčovičová A, Hrstka Z, Wichsová J, Zaviš M Abstract The main objective of this study is to describe the most common childhood diseases occurring in the Theresienstadt ghetto during the Second World War as well as applied anti-epidemic measures. A partial objective is to describe medical and nursing care of sick child prisoners. The data was obtained by the method of synthesis of primary and secondary data with the highest importance after adequate external source criticism using selected monographs, memoirs, survivor diaries, Orders of the day by ...
“Clinical Practice Guidelines for the Diagnosis and Management of Acute Otitis Media in Children—2018 update (2018 Guidelines)” aim to provide appropriate recommendations about the diagnosis and management of children with acute otitis media (AOM), including recurrent acute otitis media (recur rent AOM), in children under 15 years of age. These evidence-based recommendations were created with the consensus of the subcommittee members, taking into consideration unique characteristics of bacteriology and antimicrobial susceptibilities of AOM pathogens in Japan, as well as global advances in vaccines.
Publication date: Available online 19 May 2020Source: Journal of Microbiology, Immunology and InfectionAuthor(s): Chih-Ho Chen, Chyi-Liang Chen, Adriano Agueras, Jo Southern, Chang-Chun Hsiao, Cheng-Hsun Chiu