Interleukin-10 Deficiency Alters Endothelial Progenitor Cell -Derived Exosome Reparative Effect on Myocardial Repair via Integrin-Linked Kinase Enrichment.

Conclusions: IL-10 deficiency/inflammation alters EPC derived exosome function, content and therapeutic effect on myocardial repair by upregulating ILK enrichment in exosomes and ILK-mediated activation of NFĸB pathway in recipient cells while ILK knockdown in exosomes attenuates NFĸB activation and reduces inflammatory response. Our study provides new understanding of how inflammation may alters stem cell-exosome mediated cardiac repair and identifies ILK as a target kinase for improving progenitor cell exosome-based cardiac therapies.
PMID: 31815595 [PubMed - as supplied by publisher]

Source: Circulation Research - December 8, 2019 Category: Cardiology Authors: Yue Y, Wang C, Benedict CL, Huang G, Truongcao MM, Roy R, Cimini M, Garikipati VNS, Cheng Z, Koch WJ, Kishore R Tags: Circ Res Source Type: research