Galantamine Inhibits A β 1–42 -Induced Neurotoxicity by Enhancing α7nAChR Expression as a Cargo Carrier for LC3 Binding and Aβ 1–42 Engulfment During Autophagic Degradation

This study highlights an important new benefit with galantamine. We found that galantamine inhibits Aβ1 –42-induced apoptosis by activating the JNK signaling pathway, thus enhancing α7nAChR expression, and also inhibits the Akt pathway, which further increases autophagosome biogenesis and autophagy. These effects can be reproduced by α7nAChR overexpression in the absence of galantamine. Importantly, the α7 subunit protein sequence of α7nAChRs contains 3 LC3-interacting regi ons; our immunoprecipitation data show that α7 binds with the autophagosomal marker protein LC3. This is the first report to provide evidence showing that the cell surface receptor α7nAChR acts as a cargo carrier for LC3 binding for Aβ1 –42 sequestration to autophagosomes, suggesting a novel mechanism for the neuroprotective efficacy of galantamine in AD.
Source: Neurotherapeutics - Category: Neurology Source Type: research

Related Links:

Authors: Cosentino E, Palmer K, Della Pietà C, Mitolo M, Meneghello F, Levedianos G, Iaia V, Venneri A Abstract AIMS: To assess the correlation between cognitive functioning and 3 gait parameters (gait speed, cadence, and stride length) in persons with mild cognitive impairment (MCI) and cognitively healthy controls and investigate linear correlations between gait and gray matter volumes. MATERIALS AND METHODS: Participants were recruited at IRCCS San Camillo Hospital, Venice, Italy (MCI=43; age-matched controls=43). Participants underwent comprehensive neuropsychological assessment. Gait speed, cadence,...
Source: Alzheimer Disease and Associated Disorders - Category: Psychiatry Tags: Alzheimer Dis Assoc Disord Source Type: research
While most patients with Alzheimer's and Related Dementias (ADRD) prefer to die in nursing facilities, trends and factors associated with place of death for this population remain unknown.
Source: Journal of Pain and Symptom Management - Category: Palliative Care Authors: Source Type: research
Authors: Sun F, Chima E, Wharton T, Iyengar V Abstract Alzheimer's disease and related dementias (ADRD) affect over 50 million persons globally, and the number is expected to rise. In response, health ministries are developing and implementing policies and programs to systemically address the needs of individuals and families affected by ADRD. While national plans of action on ADRD are advancing among European Member States of World Health Organization (WHO), those in the Asia-Pacific and Americas are lagging behind. Since previous studies have largely ignored the Americas and Asia-Pacific-where approximately two-t...
Source: Pan American Journal of Public Health - Category: International Medicine & Public Health Tags: Rev Panam Salud Publica Source Type: research
AbstractMid-life hypertension and cerebrovascular dysfunction are associated with increased risk of later life dementia, including Alzheimer ’s disease (AD). The classical renin–angiotensin system (cRAS), a physiological regulator of blood pressure, functions independently within the brain and is overactive in AD. cRAS-targeting anti-hypertensive drugs are associated with reduced incidence of AD, delayed onset of cognitive decline, a nd reduced levels of Aβ and tau in both animal models and human pathological studies. cRAS activity is moderated by a downstream regulatory RAS pathway (rRAS), which is undera...
Source: Acta Neuropathologica - Category: Neurology Source Type: research
AIM: The clock drawing test (CDT) is widely used as a visual spatial ability test and screening test for dementia patients. The appearance frequency of qualitative errors obtained through the qualitative analysis of CDT may be related to the participant's ...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Age: Elder Adults Source Type: news
Dementia is a global health problem, with the World Health Organization estimates placing the number of afflicted persons at around 50 million worldwide.1 Without a treatment or cure, projections are that numbers will increase dramatically around the world by 2050.2 The prevalent intervention strategy has been pursuit of a drug to cure this illness or to modify the illness course. Available medications, mainly approved for use in Alzheimer's-type dementia (AD) but extended empirically to other forms, are mainly palliative with only modest benefits in a subset of patients.
Source: Journal of the American Medical Directors Association - Category: Health Management Authors: Tags: Editorial Source Type: research
Title: When Dementia Harms Speech, Native Language MattersCategory: Health NewsCreated: 1/22/2020 12:00:00 AMLast Editorial Review: 1/23/2020 12:00:00 AM
Source: MedicineNet Alzheimer - Category: Geriatrics Source Type: news
(University of British Columbia) Living near major roads or highways is linked to higher incidence of dementia, Parkinson's disease, Alzheimer's disease and multiple sclerosis (MS), suggests new research published this week in the journal Environmental Health.
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news
Molecules, Vol. 25, Pages 503: White Matter and Neuroprotection in Alzheimer’s Dementia Molecules doi: 10.3390/molecules25030503 Authors: Lorenzini Fernandez Baldassarro Bighinati Giuliani Calzà Giardino Myelin is the main component of the white matter of the central nervous system (CNS), allowing the proper electrical function of the neurons by ensheathing and insulating the axons. The extensive use of magnetic resonance imaging has highlighted the white matter alterations in Alzheimer’s dementia (AD) and other neurodegenerative diseases, alterations which are early, exten...
Source: Molecules - Category: Chemistry Authors: Tags: Review Source Type: research
CONCLUSION: Specialised home palliative care services may be suboptimal, and primary care services may serve as a key access point in providing baseline palliative care to people with conditions needing palliative care. Therefore, primary care services should aim to enhance their palliative care workforce. PMID: 31971075 [PubMed - as supplied by publisher]
Source: Palliative Medicine - Category: Palliative Care Authors: Tags: Palliat Med Source Type: research
More News: Alzheimer's | Brain | Dementia | Gastroenterology | Neurology | Study