USPSTF Recommendation: Screening for Abdominal Aortic Aneurysm

Interview with Michael J. Barry, MD, USPSTF member and coauthor of Screening for Abdominal Aortic Aneurysm: US Preventive Services Task Force Recommendation Statement
Source: JAMA Author Interviews - Category: General Medicine Authors: Source Type: podcasts

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We report the genetic variants associated with alpha ‐1 antitrypsin deficiency (AATD) in 117 patients admitted to our outpatient clinic and characterized by a serum concentration of AAT lower than 113 mg/dL. We focused on the M‐like heterozygous variant of theSERPINA1 gene called PI*MMMalton, and describe three patients with this variant. While the role of homozygous AATD in liver and pulmonary disease is well established, the association between heterozygous AATD and chronic liver and pulmonary disease is still under investigation. The PI*MMMalton genotype was found in 5.8% of patients with a pathological genot...
Source: Respirology Case Reports - Category: Respiratory Medicine Authors: Tags: Case Series Source Type: research
Authors: Baldino G, Rossi UG, Di Gregorio S, Gori A Abstract Percutaneous endovascular abdominal aortic aneurysm repair is nowadays considered a safe and effective procedure and has gained widespread globally acceptance. However, intraoperative persistent bleeding due to percutaneous access closure device failure can occur. Open conversion is first-line treatment to manage this complication. The fascia suture technique was introduced as an alternative to access closure device or as a solution to manage unsatisfactory hemostasis during percutaneous endovascular abdominal aortic aneurysm repair. In this article, we r...
Source: The Journal of Vascular Access - Category: Surgery Tags: J Vasc Access Source Type: research
In an intuitive retrospective study of 404 endovascular aneurysm repair (EVAR) patients, Oliveira-Pinto et  al.1 investigated the relationship between pre-operative abdominal aortic aneurysm (AAA) sac luminal volume (i.e. sac volume minus thrombus volume) and aneurysm related morbidity, secondary interventions, and mortality. The authors found that patients in the highest luminal volume quartile had sig nificantly wider, shorter, and more angulated proximal necks. Additionally, these high luminal volume AAAs demonstrated a significantly increased five year risk of AAA related complications which remained robust even a...
Source: European Journal of Vascular and Endovascular Surgery - Category: Surgery Authors: Tags: Invited Commentary Source Type: research
Abstract Current guidelines for abdominal aortic aneurysm (AAA) repair are primarily based on the maximum diameter. Since these methods lack robustness in decision making, new image-based methods for mechanical characterization have been proposed. Recently, time-resolved 3D ultrasound (4D US) in combination with finite element analysis was shown to provide additional risk estimators such as patient-specific peak wall stresses and wall stiffness in a non-invasive way. The aim of this study is to: 1) assess the reproducibility of this US-based stiffness measurement in vitro and in vivo, and 2) verify this 4D US stif...
Source: Journal of the Mechanical Behavior of Biomedical Materials - Category: Materials Science Authors: Tags: J Mech Behav Biomed Mater Source Type: research
Authors: Legaki E, Siasos G, Klonaris C, Athanasiadis D, Patelis N, Sioziou A, Oikonomou E, Liakakos T, Gazouli M, Tousoulis D PMID: 32088330 [PubMed - as supplied by publisher]
Source: Hellenic Journal of Cardiology - Category: Cardiology Tags: Hellenic J Cardiol Source Type: research
In this study, we revealed the expression and the pathogenesis of TRPV1 in a mouse AAA model. The results presented here identify TRPV1 could be a potential therapeutic target for AAA treatment. PMID: 32079471 [PubMed - in process]
Source: Channels - Category: Molecular Biology Tags: Channels (Austin) Source Type: research
Abstract Aortic aneurysm is a permanent focal dilation of the aorta. It is usually an asymptomatic disease, but can lead to sudden death due to aortic rupture. Aortic aneurysm-related mortalities are estimated at approximately 200,000 deaths per year worldwide. Since no pharmacological treatment has been found to be effective so far, surgical repair remains the only treatment for aortic aneurysm. Aortic aneurysm results from changes in the aortic wall structure due to loss of smooth muscle cells and degradation of the extracellular matrix, and can form in different regions of the aorta. Research over the past deca...
Source: American Journal of Physiology. Heart and Circulatory Physiology - Category: Physiology Authors: Tags: Am J Physiol Heart Circ Physiol Source Type: research
Abdominal aortic aneurysm (AAA) is a life-threatening disease, and the only curative treatment relies on open or endovascular repair. The decision to treat relies on the evaluation of the risk of AAA growth and rupture, which can be difficult to assess in practice. Artificial intelligence (AI) has revealed new insights into the management of cardiovascular diseases, but its application in AAA has so far been poorly described. The aim of this review was to summarize the current knowledge on the potential applications of AI in patients with AAA.
Source: Journal of Vascular Surgery - Category: Surgery Authors: Source Type: research
There is a growing body of literature raising concerns about the long-term durability of endovascular aneurysm repair (EVAR) for abdominal aortic aneurysms (AAAs), suggesting that long-term outcomes may be better after open AAA repair. However, the data investigating these long-term outcomes largely originate from early in the endovascular era and therefore do not account for increasing clinical experience and technologic improvements. We investigated whether 4-year outcomes after EVAR and open repair have improved over time.
Source: Journal of Vascular Surgery - Category: Surgery Authors: Source Type: research
Increasing experience and improving technology have led to the expansion of endovascular aneurysm repair (EVAR) for ruptured abdominal aortic aneurysms (AAA). We investigated whether the 5-year survival after both EVAR and open repair for ruptured AAA changed over the last 14  years.
Source: Journal of Vascular Surgery - Category: Surgery Authors: Source Type: research
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