Pharmacokinetics of meropenem in burn patients with infections caused by Gram-negative bacteria: Are we getting close to the right treatment?
ConclusionThese data suggest that a combined 2-h infusion with a higher dosage of meropenem, including a loading dose, may be successful to achieve effective PK parameters.
This article describes details of each stage of the mission and includes a discussion of key aspects of logistics and patient care posed by such evacuations. PMID: 31977424 [PubMed - in process]
Abstract A landmark report highlights clinician burnout and offers recommendations. PMID: 31977407 [PubMed - in process]
This study evaluated the association of concentrations of plasma penKid with death and risk of acute kidney injury (AKI) in severely ill burn patients.MethodsA prospective observational study in two centers with severely ill adult burn patients was conducted. The inclusion criteria were total body surface area (TBSA) burns>15%, with burn injury occurring
This study shows tunnel protected with calcium silicate board results in higher temperature and heat fluxes compare to non-protected tunnel and tunnel protected with magnesium oxides/Cement based spray. This indicates that passive fire protection system can alter the thermal conditions inside the tunnel in case of fire.
Patients with significant burn injuries likely have palliative care needs. We performed a systematic review of existing evidence concerning the palliative care needs of burn patients.
ConclusionsResults of the present study show that antimicrobial resistance in CNSAB isolates from burn wound infections in monitored hospitals in Iran is multifactorial, and also findings of the study suggested that local antibiotic prescription policies should be regularly reviewed, and efficient infection control measures should be observed. Therefore, further strengthening of surveillance of antimicrobial resistance is urgently needed in these regions.
ConclusionThe prevalence of MDR-GNB in Iranian burn patients is very high. Thus, a comprehensive infectious control programme, a reduction in the use of antibiotic prophylaxis, and thorough information regarding antimicrobial resistance patterns is required.
Conclusion The present results demonstrated that Chilean salmon farms play an important role as reservoirs of sulfonamide- and trimethoprim-resistant bacteria. The prevalence of conjugative plasmids and integrons among sul-carrying bacteria suggests these bacteria, mainly belonging to the Pseudomonas genus may contribute to high spread of bacterial resistance to sulfonamides and other antibacterials in environments associated with Chilean salmon farms. This is the first study reporting the occurrence of transferable sul and dfr genes and integrons among the antimicrobial resistant bacteria associated with Chilean salmonid...
Conclusions The elevated prevalence of MDR A. baumannii strains in this burn centre suggests that local antibiotic prescription policies should be precisely revised. Moreover, strict infection control procedures to prevent further dissemination need to be prioritised immediately.
Carrie Arnold is a freelance science writer living in Virginia. Her work has appeared in Scientific American, Discover, New Scientist, Smithsonian, and more. Background image: Reprinted by permission from Macmillan Publishers Ltd: doi:10.5923/s.microbiology.201401.02 About This Article open Citation: Arnold C. 2015. Outbreak breakthrough: using whole-genome sequencing to control hospital infection. Environ Health Perspect 123:A281–A286; http://dx.doi.org/10.1289/ehp.123-A281 Published: 1 November 2015 PDF Version (2.7 MB) The level of detail provided by whole-genome sequencing could give hospita...