SMC recommendation of self-injection formulation of abatacept
The Scottish Medicines Consortium (SMC) has announced that abatacept solution for subcutaneous injection (Orencia® SC) has been accepted for use within NHS Scotland, in combination with methotrexate (MTX), as a first-line biologic agent for adults with severe rheumatoid arthritis (RA), after failure with conventional disease modifying anti-rheumatic drugs (DMARDs).
Publication date: Available online 16 August 2018Source: Journal of the Taiwan Institute of Chemical EngineersAuthor(s): Guo-Sheng Zou, Su-Juan Li, Shao-ling Zheng, Xia Pan, Zheng-ping HuangAbstractWe investigated the effect of a lemon-peel extract in a rat model of rheumatoid arthritis and SW1353 chondrocytes. The rats were divided into control (sham), rheumatoid arthritis (control), extract (150 mg/kg bwt) and extract (300 mg/kg bwt) groups. Pyrogallic acid, caffeic acid, eugenol, p-coumaric acid, p‑hydroxyl benzoic acid, resorcinol, salicylic acid, luteoline, quercetin, chrysin, and luteolin-3‑methoxy‑7-rutino...
Publication date: Available online 16 August 2018Source: Annals of Physical and Rehabilitation MedicineAuthor(s): BONNIN Armand, PEREIRA Bruno, POURTIER-PIOTTE Claire, THOMAS Eric, TOURNADRE Anne, SOUBRIER Martin, COUDEYRE Emmanuel
ConclusionWe anticipated that E. longifolia that enhances bone regeneration on the one hand and suppresses osteoclast’s maturation on the other hand may have great therapeutic value in treating osteoporosis and other bone-erosive diseases such as rheumatoid arthritis and metastasis associated with bone loss.
Maria Luisa Dupuis, Fabrizio Conti, Angela Maselli, Maria Teresa Pagano, Anna Ruggieri, Simona Anticoli, Alessandra Fragale, Lucia Gabriele, Maria Cristina Gagliardi, Massimo Sanchez, Fulvia Ceccarelli, Cristiano Alessandri, Guido Valesini, Elena Ortona, Marina Pierdominici
ConclusionIt is the first COPCORD study in an urban native population living at high altitude in Peru. The population affected by chronic rheumatic disease preferred professional rather than traditional care; this population had access to limited medical services. Impaired functional capacity measured by HAQ was associated with advanced age.ResumenObjetivoEstimar la prevalencia de manifestaciones musculoesqueléticas y discapacidad en la población urbana habitante a gran altura de Juliaca, Puno, Perú; utilizando el cuestionario COPCORD y HAQ-DI.MétodosSe realizó un estudio transversal en m...
This study identified effective extracts from Eucommia ulmoides Oliv. relieving immune inflammation and maintaining structural integrity of joints in CIA rats. PMID: 30105062 [PubMed]
CONCLUSIONS Both pro-inflammatory cytokines (TNF-α and IL-6) and anti-inflammatory mediators (TIM-3 and IL-37) simultaneously contribute to the pathogenesis of RA. TIM-3 and IL-37 may be used as potential biomarkers of active RA. PMID: 30106887 [PubMed - in process]
Study Design. Retrospective review. Objective. To identify the incidence and analyze the risk of postoperative complications amongst elderly patients with rheumatoid arthritis undergoing anterior cervical fusion. Summary of Background Data. Previous studies have reported elevated risks of postoperative complications for patients with rheumatoid arthritis undergoing orthopedic procedures. However, little is known about the risk of postoperative complications in rheumatoid arthritis patients after spine surgery. Methods. A commercially available database was queried for all Medicare patients 65 years of age and ol...
What benefits might sarilumab monotherapy offer over adalimumab monotherapy in the treatment of rheumatoid arthritis?Arthritis Research &Therapy
This study also highlights the dynamic potential of aloin as a therapeutic agent to treat osteope nic disorders.