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SMC recommendation of self-injection formulation of abatacept

The Scottish Medicines Consortium (SMC) has announced that abatacept solution for subcutaneous injection (Orencia® SC) has been accepted for use within NHS Scotland, in combination with methotrexate (MTX), as a first-line biologic agent for adults with severe rheumatoid arthritis (RA), after failure with conventional disease modifying anti-rheumatic drugs (DMARDs).
Source: Pharmacy Europe - Category: Drugs & Pharmacology Source Type: news

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Source: The Anatomical Record Part A: Discoveries in Molecular, Cellular, and Evolutionary Biology - Category: Molecular Biology Authors: Tags: Full Length Article Source Type: research
We examined the functional activity of peripheral blood neutrophils and the complement system activation status in patients with rheumatoid arthritis (RA) undergoing infliximab/methotrexate combined therapy. We studied female RA patients under treatment with infliximab (3 –5 mg/kg) and methotrexate (15–25 mg/week) who presented inactive (i-RA;n = 34, DAS-28 ≤ 2.6) or at least moderately active disease (a-RA;n = 29, DAS-28 >  3.2), and age-matched healthy women (n = 38). We measured the levels of reactive oxygen species (ROS) g...
Source: Rheumatology International - Category: Rheumatology Source Type: research
Moayad Al Hadidi, Hamid Shaaban, Khalid Hani Jumean, Paloma Abi PeraltaJournal of Global Infectious Diseases 2018 10(1):29-30
Source: Journal of Global Infectious Diseases - Category: Infectious Diseases Authors: Source Type: research
AbstractTo summarize evidence concerning the articular examination needed to determine rheumatoid arthritis (RA) activity (follow-up or control) via a systematic review. A search of Medline, Embase, Lilacs, SciELO, the Web of Science, the National Technical Reports Library, and the reference lists of relevant studies through March 2017 was conducted using a systematic methodology to identify studies of patients with RA older than 18  years in which a detailed description of the physical examination or a description of the components of the articular examination was provided. Of 8322 references, 74 studies were include...
Source: Clinical Rheumatology - Category: Rheumatology Source Type: research
This study included 67 patients (F/M = 4:1) with rheumatoid arthritis, 57 (85%) bei ng RF positive and 20 receiving prednisolone at baseline. Mean (± SD) dose of methotrexate at 24 weeks was 22.9 ± 3.0 mg per week. On treatment with methotrexate, there was a significant (p = 0.04) decline in CD8+IFN γ+ cells from 37.2 (IQR 19.4 –60.2) to 22.7% (IQR 8.5–49.7) and a marginal increase in CD8+IL17+ cells from 0.3 (IQR 0.1 –0.6) to 0.4 (IQR 0.2–1.2),p = 0.006. There was no significant change in the other subsets. There ...
Source: Clinical Rheumatology - Category: Rheumatology Source Type: research
Condition:   Rheumatoid Arthritis Intervention:   Device: SetPoint Medical Neurostimulation of the Cholinergic Anti-inflammatory Pathway System Sponsor:   SetPoint Medical Corporation Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Conclusion Intra-articular knee implantation of MSCs appeared to be safe and well tolerated. In addition, we observed a trend toward clinical efficacy. These results, in our opinion, have justified the need for further investigations over an extended assessment period with larger numbers of RA patients who have knee involvement.
Source: Cytotherapy - Category: Cytology Source Type: research
Source: Arthritis and Rheumatism - Category: Rheumatology Authors: Tags: Letters Source Type: research
ConclusionBetween 1993 and 2013, the proportion of hospitalizations for infections among RA patients appeared to decline for pneumonia and OIs, with a slight decrease in UTI, a slight increase in SSTIs, and a substantial increase in hospitalizations with sepsis. Our results are consistent with previous reports that the sensitivity of sepsis coding has increased over time.
Source: Arthritis Care and Research - Category: Rheumatology Authors: Tags: Brief Report Source Type: research
The objective of this study was to estimate posturographic trajectories applying pattern recognition algorithms. To this end, k-nearest neighbors (k-NN) classifier was used to differentiate between healthy subjects and patients with OA and RA. The following parameters of trajectories were computed: radius of sways, developed area, total length, and two directional components of sways: length of left-right and forward-backward motions. Posturographic tests were applied with eyes open and closed, and with biofeedback control. We found that in RA, the radius of sways, the trajectory area, and the biofeedback coordination were...
Source: Advances in Experimental Medicine and Biology - Category: Research Tags: Adv Exp Med Biol Source Type: research
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