SMC recommendation of self-injection formulation of abatacept
The Scottish Medicines Consortium (SMC) has announced that abatacept solution for subcutaneous injection (Orencia® SC) has been accepted for use within NHS Scotland, in combination with methotrexate (MTX), as a first-line biologic agent for adults with severe rheumatoid arthritis (RA), after failure with conventional disease modifying anti-rheumatic drugs (DMARDs).
Vitamin D is a crucial nutrient for bone health. Some studies suggest a link between vitamin D deficiency and joint or muscle pain, including rheumatoid arthritis. In this article, we look at what the research says, how a person can get their daily dose of vitamin D, and other vitamins that could help joint pain.
This study was performed to examine whether the AF4/FMR2 family, member 1 (AFF1) rs340630 polymorphism is involved in the genetic background of rheumatoid arthritis (RA) in a Chinese population. Two different study groups of RA patients and controls (328 RA patients and 449 healthy controls in the first study group; 232 RA patients and 313 controls in the second study group) were included in our study. Overall, there was no significant difference in either genotype (P=0.71 and 0.64 in the first and second study group, respectively) nor allele (in the first study group: A vs G, P=0.65, OR=1.05, 95%CI=0.85-1.29; in the secon...
We reported that a unique PD-1+ MP CD4+ T cell population is increased with age, now termed senescence-associated (SA-) T cells. The SA-T cells show characteristic signs and features of cellular senescence and emerge as follicular T cells in spontaneous germinal centers (GCs) that occur in aged mice. Spontaneous development of GCs is a hallmark of systemic autoimmune diseases, and among a number of changes in immune function with age is an increasing risk for autoimmunity. Link: https://www.ncbi.nlm.nih.gov/books/NBK500331/
CONCLUSION: FA-PSA-CC micelles demonstrated significant advantages in terms of the suppression of inflammation and the treatment of inflammatory arthritis. These reliable and stable micelles possess a high potential to be transferred for clinical use. PMID: 29790372 [PubMed - in process]
Publication date: Available online 24 May 2018 Source:Biocatalysis and Agricultural Biotechnology Author(s): S. Srividya, G. Sridevi, B. Santhosh Kumar, T.P. Sastry Allogenous grafts with excellent biocompatibility and immuno-compatibility play a major role in most of the biomedical applications. In this regard, the present study focuses on fabricating a novel bone graft material containing biopolymers and phytochemicals which can replace the use of autogenous graft with high biocompatibility and osteogenecity. Based on this, a bone graft material was synthesized using biphasic calcium phosphate (BCP), casein (CA), hen eg...
Genome-wide association study of response to methotrexate in early rheumatoid arthritis patients, Published online: 25 May 2018; doi:10.1038/s41397-018-0025-5Genome-wide association study of response to methotrexate in early rheumatoid arthritis patients
Yanqiong Zhang, Hailong Wang, Xia Mao, Qiuyan Guo, Weijie Li, Xiaoyue Wang, Guangyao Li, Quan Jiang, Na Lin
There are many types of arthritis. Psoriatic arthritis is linked to the skin condition psoriasis, where the immune system overreacts, resulting in psoriasis rashes. Rheumatoid arthritis also causes the immune system to overreact, but results in stiffness in the joints. Learn about the difference between the two here.
Condition: Rheumatoid Arthritis Intervention: Drug: Methotrexate Sponsors: Juan Carlos Nieto; Nordic Pharma SAS Not yet recruiting
ACS Chemical BiologyDOI: 10.1021/acschembio.8b00118